Results 91 to 100 of about 221,282 (257)
A Philosophical Approach to Animal Rights and Welfare in the Tourism Sector
Journal of Tourism, Leisure and Hospitality, 2019 Although studies on animal rights and welfare in the field of tourism have begun to emerge in recent years, the subject is still new. In this context, a philosophical approach to animal rights and welfare in the tourism sector is put forward in this ...
Günlü Küçükaltan, Ebru +1 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Health, environmental, and animal rights motives for vegetarian eating. [PDF]
PLoS One, 2020 Hopwood CJ +3 more
europepmc +1 more source
RelationsThe white-elitist veganism of the Global North does not adequately respond to the territorial, cultural, and economic particularities of the Latin American region.
Juan José Ponce León
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
ANIMAL ISSUES IN THE POLITICAL AND LEGAL SPHERE IN RUSSIA AND ABROAD
Правовое государство: теория и практикаIn Russia, the issue of the status of animals is at a medieval level, and it is extremely difficult to resolve it without ethical reflection. The purpose of the article is to consider a current problem concerning the status of animals.
BEZNOSOVA Yana Viktorovna +2 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source