Results 121 to 130 of about 923,548 (275)

Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing

, 2023
Nupur Kohli, Konstantinos Theodoridis, Thomas A. Hall, Inigo Sanz-Pena, David Gaboriau, Richard J. van Arkel   +5 more
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

JACC: Basic to Translational Science, 2019
Summary: Animal testing is used in pharmaceutical and industrial research to predict human toxicity, and yet analysis suggests that animal models are poor predictors of drug safety in humans. The cost of animal research is high—in dollars, delays in drug
Gail A. Van Norman, MD
doaj  

Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard

Frontiers in Bioengineering and Biotechnology
Over the past decade, the development of nanomaterials (NMs) has surged, highlighting their potential benefits across multiple industries. However, concerns regarding human and environmental exposure remain significant.
Roma Fraser, Keira Campbell, Pawel Pokorski, Eve MacKinnon, Katie McAllister, Karla B. Neves, Fiona Murphy   +6 more
doaj   +1 more source

Assessment of the Ocular Irritation Potential of Pesticides using Reconstructed Human Cornea-like Epithelium (RhCE) Model as Alternatives to Animal Testing [PDF]

, 2018
Youmi Jo, Ju‐Yeun Lee, Soo‐Jin Park, Are-Sun You, Jin A Oh, Je Bong Lee, Yeon-Ki Park, Mi-Hye Jeong   +7 more
openalex   +1 more source

[Legal aspects of alternative methods to animal testing].

Biologie aujourd'hui, 2023
Si le remplacement total de l’expérimentation animale était l’objectif visé par la directive européenne du 22 septembre 2010 relative à la protection des animaux utilisés à des fins scientifiques, force est de constater qu’il est encore loin d’être atteint. Le nombre d’animaux ne diminue pas et les méthodes alternatives peinent à être utilisées.
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

ReBiA—Robotic Enabled Biological Automation: 3D Epithelial Tissue Production

Advanced Science
The Food and Drug Administration's recent decision to eliminate mandatory animal testing for drug approval marks a significant shift to alternative methods.
Lukas Königer, Christoph Malkmus, Dalia Mahdy, Thomas Däullary, Susanna Götz, Thomas Schwarz, Marius Gensler, Niklas Pallmann, Danjouma Cheufou, Andreas Rosenwald, Marc Möllmann, Dieter Groneberg, Christina Popp, Florian Groeber‐Becker, Maria Steinke, Jan Hansmann   +15 more
doaj   +1 more source

Alternatives for Animal Testing: A More Humane Approach To Clinical Research

, 2023
Santosh Kumar, Namrata Dagli, Mainul Haque   +2 more
openalex   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source