Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Social Sciences in One Health: Insights From Multiple Worlds Perspectives on the Dam Rupture in Brumadinho-Brazil. [PDF]
Front Public Health, 2021 Brandão APD +4 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Animalistic dehumanisation as a social influence strategy. [PDF]
Front Psychol, 2022 Quiamzade A, Lalot F.
europepmc +1 more source
Animality and Ideology in Contemporary Economic Discourse:Taxonomizing Homo Economicus [PDF]
, 2013 Akerlof G. A. +30 more
core +1 more source
Two Modes of Non-Thinking. On the Dialectic Stupidity-Thinking and the Public Duty to Think [PDF]
, 2018 This article brings forth a new perspective concerning the relation between stupidity and thinking by proposing to conceptualise the state of non-thinking in two different ways, situated at the opposite ends of the spectrum of thinking.
Marin, Lavinia
core
LiminAnimal: The Monster in Late Victorian Gothic Fiction
, 2015 The animal characteristics of the monster in late Victorian gothic fiction make visible the biopolitical rationalisation of life in modern societies. Key moments in Bram Sto- ker’s Dracula and R.L.
Mario Ortiz-Robles
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Dismissals for Social Media Hate Speech in South Africa: Animalistic Dehumanisation and the Circulation of Racist Words and Images. [PDF]
Int J Semiot Law, 2022 Cornish R, Tranter K.
europepmc +1 more source