Genetically Modified Rabbits for Cardiovascular Research
Frontiers in Genetics, 2021 Rabbits are one of the most used experimental animals for investigating the mechanisms of human cardiovascular disease and lipid metabolism because they are phylogenetically closer to human than rodents (mice and rats).
Jianglin Fan +4 more
doaj +2 more sources
Factors Affecting the Adoption of Genetically Modified Animals in the Food and Pharmaceutical Chains
Bio-based and Applied Economics, 2012 The production of genetically modified (GM) animals is an emerging technique that could potentially impact the livestock and pharmaceutical industries.
Cristina Mora +6 more
doaj +2 more sources
Review article Genetically modified animals for use in research and biotechnology
Genetics and Molecular Research, 2010 Transgenic animals are used extensively in the study of in vivo gene function, as models for human diseases and in the production of biopharmaceuticals. The technology behind obtaining these animals involves molecular biology techniques, cell culture and embryo manipulation; the mouse is the species most widely used as an experimental model.
Lucas Martins Chaible +3 more
openaire +4 more sources
Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models [PDF]
Endocrinology and Metabolism, 2022 The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies.
Min Ji Jeon, Bryan R. Haugen
doaj +1 more source
Genetically modified animals for use in biopharmacology: from research to production [PDF]
Research Results in Pharmacology, 2021 Introduction: In this review, the analysis of technologies for obtaining biologically active proteins from various sources is carried out, and the comparative analysis of technologies for creating producers of biologically active proteins is presented ...
Alexey V. Deykin +15 more
doaj +3 more sources
Genetically modified stem cells for osteoporosis: a systematic review and meta-analysis of preclinical studies. [PDF]
BMC Musculoskelet DisordObjective Our meta-analysis aims to assess the efficacy of genetically modified stem cell therapy in preclinical osteoporosis models. Methods We executed a thorough literature search across PubMed, Embase, Web of Science, and the Cochrane Library ...
Huang M, Wu XS, Xiao N, Huang X, Lin PF.
europepmc +2 more sources
Transgenes of genetically modified animals detected non-invasively via environmental DNA.
PLoS ONE, 2021 We demonstrate that simple, non-invasive environmental DNA (eDNA) methods can detect transgenes of genetically modified (GM) animals from terrestrial and aquatic sources in invertebrate and vertebrate systems.
Charles C Y Xu +5 more
doaj +1 more source
Genetically modified large animal models for investigating neurodegenerative diseases
Cell & Bioscience, 2021 Neurodegenerative diseases represent a large group of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease.
Weili Yang +3 more
semanticscholar +1 more source
Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice
Einstein (São Paulo), 2022 The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals.
Carolina Capobiango Romano Quintão +4 more
doaj +1 more source
The controversies of genetically modified food
IOP Conference Series: Earth and Environment, 2021 The increasing use of genetically modified (GM) foods and feeds attracts the interest of media and public, causing great concern among consumers about the consequences of their consumption.
K. Blagoevska +6 more
semanticscholar +1 more source