Results 21 to 30 of about 176,736 (219)
The effects of tail biopsy for genotyping on behavioral responses to nociceptive stimuli. [PDF]
PLoS ONE, 2009 Removal of a small segment of tail at weaning is a common method used to obtain tissue for the isolation of genomic DNA to identify genetically modified mice.
Maria Elena P Morales, Robert W Gereau
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2018 Pigs are considered as optimal donor animal for the successful xenotransplantation. To increase the possibility of clinical application, genetic modification to increase compatibility with human is an important and essential process. Genetic modification
Bumrae Cho +7 more
doaj +1 more source
Simple Genome Editing of Rodent Intact Embryos by Electroporation. [PDF]
PLoS ONE, 2015 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system is a powerful tool for genome editing in animals. Recently, new technology has been developed to genetically modify animals without using highly skilled ...
Takehito Kaneko, Tomoji Mashimo
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh +4 more
wiley +1 more source
Are good ideas enough?: The impact of socio-economic and regulatory factors on GMO commercialisation
Biological Research, 2013 In recent years scientific literature has seen an increase in publications describing new transgenic applications. Although technically-sound, these promising developments might not necessarily translate into products available to the consumer.
Núria Vàzquez-Salat
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Efficient In Vivo Introduction of Point Mutations Using ssODN and a Co-CRISPR Approach
Biological Procedures Online, 2020 Background The generation of point mutations is a major tool for evaluating the roles of specific nucleotides or amino acids within the regulatory or functional landscape. However, examination of these mutations in vivo requires the generation of animals
Tgst Levi +4 more
doaj +1 more source
Genetically Modified Rabbits for Cardiovascular Research
Frontiers in Genetics, 2021 Rabbits are one of the most used experimental animals for investigating the mechanisms of human cardiovascular disease and lipid metabolism because they are phylogenetically closer to human than rodents (mice and rats).
Jianglin Fan +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Neural circuits mediating olfactory-driven behavior in fish
Frontiers in Neural Circuits, 2013 The fish olfactory system processes odor signals and mediates behaviors that are crucial for survival such as foraging, courtship and alarm response. Although the upstream olfactory brain areas (olfactory epithelium and olfactory bulb) are well studied ...
Florence eKermen +9 more
doaj +1 more source