Results 21 to 30 of about 175,605 (302)

Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice

Einstein (São Paulo), 2022
The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals.
Carolina Capobiango Romano Quintão, Luiz Sérgio de Almeida Camargo, Humberto de Mello Brandão, Naiara Zoccal Saraiva, Michele Munk   +4 more
doaj   +1 more source

Current status of the application of gene editing in pigs

The Journal of Reproduction and Development, 2021
Genetically modified animals, especially rodents, are widely used in biomedical research. However, non-rodent models are required for efficient translational medicine and preclinical studies.
Fuminori TANIHARA, Maki HIRATA, Takeshige OTOI   +2 more
doaj   +1 more source

Cutaneous melanoma in genetically modified animals [PDF]

Pigment Cell Research, 2007
AbstractCutaneous melanomas are tumors originating from skin melanocytes which are present in hair follicles, and interfollicular epidermal and dermal layers. Experimental work in model systems involves in silico, in vitro and in vivo analyses. Such models allow to mimick melanocytic aberrations characteristic of melanoma, and to potentially exploit ...
Lionel, Larue, Friedrich, Beermann
openaire   +2 more sources

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

Frontiers in Cell and Developmental Biology, 2022
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang, Lichen Zhang, Wushan Li, Wushan Li, Zhuangzhuang Liu, Zhuangzhuang Liu, Yang Liu, Yang Liu, Zhilong Liu, Zhilong Liu, Yanrong Gu, Yanrong Gu, Le He, Le He, Binhui Zhou, Binhui Zhou, Tianhan Li, Tianhan Li, Tianzhu Chao, Tianzhu Chao, Yinming Liang, Yinming Liang, Yinming Liang, Liaoxun Lu, Liaoxun Lu, Liaoxun Lu   +25 more
doaj   +1 more source

Use of rodents as models of human diseases

Journal of Pharmacy and Bioallied Sciences, 2014
Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers.
Thierry F Vandamme
doaj   +1 more source

Effects of Genetically Modified Food on Gut Microbiota in Animal Models: A Systematic Review [PDF]

Journal of Health Sciences and Surveillance System
Background: There are some debates about the possible unintended effects of genetically modified (GM) crops on consumer health. The gut microbiota plays an important role in maintaining the health of the host, especially in gastrointestinal diseases. The
Maryam Nejabat, Mohammadreza Heydari, Parisa Keshani, Hassan Joulaei, Nazanin Nazari   +4 more
doaj   +1 more source

Prevalence of genetically modified soybean in animal feedingstuffs in Poland [PDF]

Journal of Veterinary Research, 2021
Abstract Introduction Globally, genetically modified (GM) crops were grown on 191.7 million hectares in 2018, which were mostly sown with soybean, maize, cotton, oilseed rape, and rice. The most popular traits introduced through genetic modification include herbicide and pest insect resistance.
Sieradzki Zbigniew, Mazur Małgorzata, Król Beata, Kwiatek Krzysztof   +3 more
openaire   +3 more sources

Regulation on Genetically Modified Animals: Proposed and Its Possible Application in Indonesia [PDF]

, 2021
The government is responsible for fulfil the needs of safe, healthy and halal food for all its people in a sustainable manner. The world population will increase from 7 to 9 billion people in 2050.
Tiesnamurti, Bess, Muharsini, Sri, Shiddieqy, M I   +2 more
core   +1 more source

Modern approaches to production of safe and effective genetically modified rabies vaccines for animals

Ветеринария сегодня, 2023
Rabies is a dangerous zoonoticdisease that affects the central nervous system, causes encephalomyelitis and paralyses and Is almost invariably fatal.
M. I. Doronin, A. Mazloum, D. V. Mikhalishin, M. N. Mitrofanova, A. Yu. Sukharkov, V. V. Kiseleva, A. V. Sprygin   +6 more
doaj   +1 more source

Factors Affecting the Adoption of Genetically Modified Animals in the Food and Pharmaceutical Chains

Bio-based and Applied Economics, 2012
The production of genetically modified (GM) animals is an emerging technique that could potentially impact the livestock and pharmaceutical industries.
Cristina Mora, Davide Menozzi, Gijs Kleter, Lusine H. Aramyan, Natasha I. Valeeva, Karin l. Zimmermann, Giddalury Pakki Reddy   +6 more
doaj   +1 more source