Results 201 to 210 of about 485,436 (276)

Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

Ono Y, Peterka M, Love M, Bhandari A, Gordon E, Ball JS, Tyler CR, Rees S, Bohlooly-Y M, Maresca M, Scholpp S.   +10 more
europepmc   +1 more source

Effects of genetically modified soybean on physiological variables and gut microbiota of Sprague-Dawley rats. [PDF]

PLoS One
Ashrafi-Dehkordi E, Alborzi A, Pouladfar G, Abbasian SA, Mazloomi SM.   +4 more
europepmc   +1 more source

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

Advanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo   +10 more
wiley   +1 more source

The current issues of translating clinical xenokidney transplantation, with an emphasis on prevention of rejection. [PDF]

Front Transplant
Kwun J, Ladowski JM, Jackson AM, Knechtle S.   +3 more
europepmc   +1 more source

Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures

Advanced Healthcare Materials, EarlyView.
SiNW mat‐based MEA (NW_MEA) enables continuous intracellular recordings from neurons in primary rat DRG cell cultures, identifying C‐fiber nociceptors. Supported by an astrocyte feeder layer, SiNW mat promotes DRG neuron and glial cell growth, preserving in vivo‐like cell characteristics and allowing drug‐modulated activity monitoring.
Ivano Lucarini, Francesco Maita, Giorgia Conte, Emanuela Saracino, Francesco Formaggio, Elena Palmieri, Roberta Fabbri, Aikaterini Konstantoulaki, Chiara Lazzarini, Marco Caprini, Valentina Benfenati, Luca Maiolo, Annalisa Convertino   +12 more
wiley   +1 more source

Safety evaluation of the food enzyme acetolactate decarboxylase from the genetically modified <i>Bacillus subtilis</i> strain DP-Ezz65. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, L M Solano M, Sramkova M, Van Loveren H, Vernis L, Andryszkiewicz M, Cavanna D, Fernàndez-Fraguas C, Peluso S, Liu Y.   +18 more
europepmc   +1 more source

CLDN18.2 CAR‐derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer

Advanced Healthcare Materials, EarlyView.
CLDN18.2 CAR‐T cell‐derived small extracellular vesicles (CAR‐sEVs) display potent cytotoxicity and prolong survival in preclinical pancreatic cancer models. They contain functional CAR proteins and granzyme B, exhibit antigen specificity, and effectively target tumor cells while sparing healthy cells.
Yue Qing, Ke Jiang, Hua Jiang, Yaru Zhao, Chu‐Hu Lai, Alexandra Aicher, Zonghai Li, Christopher Heeschen   +7 more
wiley   +1 more source

Safety evaluation of the food enzyme chymotrypsin from the genetically modified <i>Bacillus licheniformis</i> strain NZYM-RH. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Sramkova M, Van Loveren H, Vernis L, Cocconcelli PS, Aguilera J, Andryszkiewicz M, Cavanna D, Liu Y.   +18 more
europepmc   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Progress in Porcine Kidney Transplantation to Non-Human Primates. [PDF]

Transpl Int
Le Bas-Bernardet S, Blancho G.
europepmc   +1 more source