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Genetically Modified Animals and Pharmacological Research
Handbook of Experimental Pharmacology, 2010This chapter reviews the use of genetically modified animals and the increasingly detailed knowledge of the genomes of the domestic species. The different approaches to genetic modification are outlined as are the advantages and disadvantages of the techniques in different species.
D. Wells
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Attitudes towards the use of genetically modified animals in research
Public Understanding of Science, 2010Here we provide the first experimental evidence that public concerns about the use of animals in research are accentuated when genetically modified (GM) animals are used. Using an online survey, we probed participant views on two uses of pigs as research animals (to reduce agricultural pollution or to improve organ transplant success in humans) with ...
Daniel M. Weary, Catherine A. Schuppli
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2012
AbstractThis article considers the extraordinary ways in which it is now possible to alter animals and to create new life forms by transgenesis and by the creation of hybrids and chimeras. Transgenic animals are created by transferring genes from one species to another.
J. Savulescu
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AbstractThis article considers the extraordinary ways in which it is now possible to alter animals and to create new life forms by transgenesis and by the creation of hybrids and chimeras. Transgenic animals are created by transferring genes from one species to another.
J. Savulescu
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Genetically modified animals and immunodeficiency
Current Opinion in Immunology, 1993Mouse strains with defined genetic defects engineered by the method of targeted gene disruption and homologous recombination have furthered our understanding of immune functions at the single gene level. More importantly, these mutant 'gene knockout' mice are powerful in vivo tools to dissect the complex mechanisms of lymphocyte development and ...
Tak W. Mak +2 more
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An algorithm for the identification of genetically modified animals
Trends in Biotechnology, 2013The diffusion of genetically modified (GM) animals has generated a demand for accurate and unique identification to assure compliance with relevant national and international legislation. Individual identification of GM animals is essential to improve safety and traceability, as well as to fulfill the present and future expectations of producers ...
Fredrik Sundström +2 more
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Patents for genetically modified animals
Journal of Animal Science, 1993Should genetically engineered animals be patented? This issue has been one of the most contentious as lawmakers have grappled with how best to protect intellectual property. Since the 1980 case of Diamond v. Chakrabarty, in which the U.S. Supreme Court ruled that a living microorganism is patentable, the U.S.
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The program for phenotyping of genetically modified animals at AstraZeneca
Experimental and Toxicologic Pathology, 2006Genetically modified mice offer a wide range of possibilities in preclinical drug discovery, e.g. for use in target identification, target validation and disease model generation. However, genomic modification and alteration in gene expression may cause unpredicted phenotypic alterations in the organism other than the intended ones.
Mohammad Bohlooly-Y, Anna-Lena Berg
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Genetically Modified Animal Models
2013Genetically modified animals were first created in the 1970s–1980s, and are considered good models of human diseases. In this chapter, the types of genetically engineered mice, like transgenic, knockout, conditional knockout and knock-in animals, are presented.
Lucas Martins Chaible +3 more
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Genetically modified animals: ethical issues
Journal of Animal Science, 1993The method of ethical analysis is reviewed and applied to questions relating to the unintended consequences, ownership, and metaphysical significance of genetically modified animals. The question of how genetics and recombinant DNA discoveries have an impact on human understanding of the moral community and the limits of acceptable action are ...
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Animal nutrition with feeds from genetically modified plants [PDF]
Archives of Animal Nutrition, 2005 Plant breeders have made and will continue to make important contributions toward meeting the need for more and better feed and food. The use of new techniques to modify the genetic makeup of plants to improve their properties has led to a new generation of crops, grains and their by-products for feed.
Gerhard Flachowsky +2 more
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