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Welfare Issues of Genetically Modified Animals [PDF]
ILAR Journal, 2002 Genetically engineered animals have opened new frontiers in the study of physiology and disease processes. Mutant animals offer more accurate disease models and increased precision for pathogenesis and treatment studies. Their use offers hope for improved therapy to patients with conditions that currently have poor or ineffective treatments.
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Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019 Rat line lacking the dopamine transporter (DAT-KO rats) was recently developed. Lack of DAT in these mutants manifests behaviorally as spontaneous hyperactivity and cognitive deficits.
I. Sukhanov +5 more
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The effects of tail biopsy for genotyping on behavioral responses to nociceptive stimuli. [PDF]
PLoS ONE, 2009 Removal of a small segment of tail at weaning is a common method used to obtain tissue for the isolation of genomic DNA to identify genetically modified mice.
Maria Elena P Morales, Robert W Gereau
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Annals of Agricultural and Environmental Medicine, 2017 Introduction Agriculture based on genetically modified organisms plays an increasingly important role in feeding the world population, which is evidenced by a considerable growth in the size of land under genetically modified crops (GM).
Stanisław Lachowski +5 more
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Simple Genome Editing of Rodent Intact Embryos by Electroporation. [PDF]
PLoS ONE, 2015 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system is a powerful tool for genome editing in animals. Recently, new technology has been developed to genetically modify animals without using highly skilled ...
Takehito Kaneko, Tomoji Mashimo
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Pharmaceutics, 2020 In vivo gene delivery involves direct injection of nucleic acids (NAs) into tissues, organs, or tail-veins. It has been recognized as a useful tool for evaluating the function of a gene of interest (GOI), creating models for human disease and basic ...
Masahiro Sato +4 more
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Journal of Animal Reproduction and Biotechnology, 2018 Pigs are considered as optimal donor animal for the successful xenotransplantation. To increase the possibility of clinical application, genetic modification to increase compatibility with human is an important and essential process. Genetic modification
Bumrae Cho +7 more
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Genetically Modified Rabbits for Cardiovascular Research
Frontiers in Genetics, 2021 Rabbits are one of the most used experimental animals for investigating the mechanisms of human cardiovascular disease and lipid metabolism because they are phylogenetically closer to human than rodents (mice and rats).
Jianglin Fan +4 more
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Are good ideas enough?: The impact of socio-economic and regulatory factors on GMO commercialisation
Biological Research, 2013 In recent years scientific literature has seen an increase in publications describing new transgenic applications. Although technically-sound, these promising developments might not necessarily translate into products available to the consumer.
Núria Vàzquez-Salat
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Efficient In Vivo Introduction of Point Mutations Using ssODN and a Co-CRISPR Approach
Biological Procedures Online, 2020 Background The generation of point mutations is a major tool for evaluating the roles of specific nucleotides or amino acids within the regulatory or functional landscape. However, examination of these mutations in vivo requires the generation of animals
Tgst Levi +4 more
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