Results 21 to 30 of about 485,436 (276)

Current status of the application of gene editing in pigs

The Journal of Reproduction and Development, 2021
Genetically modified animals, especially rodents, are widely used in biomedical research. However, non-rodent models are required for efficient translational medicine and preclinical studies.
Fuminori TANIHARA, Maki HIRATA, Takeshige OTOI   +2 more
doaj   +1 more source

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

Frontiers in Cell and Developmental Biology, 2022
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang, Lichen Zhang, Wushan Li, Wushan Li, Zhuangzhuang Liu, Zhuangzhuang Liu, Yang Liu, Yang Liu, Zhilong Liu, Zhilong Liu, Yanrong Gu, Yanrong Gu, Le He, Le He, Binhui Zhou, Binhui Zhou, Tianhan Li, Tianhan Li, Tianzhu Chao, Tianzhu Chao, Yinming Liang, Yinming Liang, Yinming Liang, Liaoxun Lu, Liaoxun Lu, Liaoxun Lu   +25 more
doaj   +1 more source

Use of rodents as models of human diseases

Journal of Pharmacy and Bioallied Sciences, 2014
Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers.
Thierry F Vandamme
doaj   +1 more source

Community Engagement and Field Trials of Genetically Modified Insects and Animals.

The Hastings center report, 2018
New techniques for the genetic modification of organisms are creating new strategies for addressing persistent public health challenges. For example, the company Oxitec has conducted field trials internationally-and has attempted to conduct field trials ...
C. Neuhaus
semanticscholar   +1 more source

Effects of Genetically Modified Food on Gut Microbiota in Animal Models: A Systematic Review [PDF]

Journal of Health Sciences and Surveillance System
Background: There are some debates about the possible unintended effects of genetically modified (GM) crops on consumer health. The gut microbiota plays an important role in maintaining the health of the host, especially in gastrointestinal diseases. The
Maryam Nejabat, Mohammadreza Heydari, Parisa Keshani, Hassan Joulaei, Nazanin Nazari   +4 more
doaj   +1 more source

Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals

Aging, 2018
It is widely accepted that caloric restriction (CR) extends lifespan and suppresses various pathophysiological changes. CR suppresses growth hormone/insulin-like growth factor signaling and mechanistic target of rapamycin complex 1 activity, activates ...
Shunsuke Hoshino, Masaki Kobayashi, Y. Higami   +2 more
semanticscholar   +1 more source

Genetically Modified Products, Perspectives and Challenges

Cureus, 2020
It is a common ground that humans have always modified the genome of both plants and animals. This intrusive process that has existed for thousands of years, many times through mistakes and failures, was initially carried out through the crossing of ...
Dimitrios T Karalis, T. Karalis, S. Karalis, Angeliki S Kleisiari   +3 more
semanticscholar   +1 more source

Impact of genetically modified organisms on meat quality [PDF]

Open Vet J
A unique class of gene biotechnology known as genetic modification modifies the genetic makeup of living things like microbes, plants, and animals. Several possible advantages and hazards associated with gene biotechnology. Due to increased food demands
Muntaha Ghazi Hasan
europepmc   +2 more sources

Modern approaches to production of safe and effective genetically modified rabies vaccines for animals

Ветеринария сегодня, 2023
Rabies is a dangerous zoonoticdisease that affects the central nervous system, causes encephalomyelitis and paralyses and Is almost invariably fatal.
M. I. Doronin, A. Mazloum, D. V. Mikhalishin, M. N. Mitrofanova, A. Yu. Sukharkov, V. V. Kiseleva, A. V. Sprygin   +6 more
doaj   +1 more source

Breeding and Maintenance of Immunodeficient Mouse Lines under SPF Conditions—A Call for Individualized Severity Analyses and Approval Procedures

Animals, 2021
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods
Thomas Kammertoens, Sarah Jeuthe, Heike Baranzke, Antonina Klippert, Christa Thöne-Reineke   +4 more
doaj   +1 more source