Results 191 to 200 of about 2,504,504 (308)

Critical uncertainties in preclinical research: Navigating trust, technology, and ethics. [PDF]

Neurosci Appl
Heinla I, Voikar V, Gates H, Bains RS, Wells S, Mandillo S, Čater M, Kukk K, Lewejohann L, Hrnčić D, Duarte-Domingues D, Villiger P, Restivo L, Hölter SM.   +13 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Object Permanence Cognitive Task Solution Using Wild Rodents. [PDF]

Animals (Basel)
Blinov DA, Perepelkina OV, Poletaeva II.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Standardized Protocols for Soil Fauna Extraction and a Call for Cross-Lab Implementation. [PDF]

Ecol Evol
Tůmová M, Lu JZ, Briones MJI, Cesarz S, Eisenhauer N, Fujii S, Gongalsky KB, Haimi J, Hohberg K, Jänsch S, Karuri H, Kitagami Y, Korobushkin DI, Lochner A, Mathieu J, Rozanova OL, Römbke J, Seeber J, Schmelz R, Schmidt O, Schneider C, Sun X, Tuma J, Zaitsev AS, Zuev AG, Potapov AM.   +25 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Differences in auditory brainstem responses between laboratory-reared and wild-caught prairie voles (Microtus ochrogaster). [PDF]

PLoS One
Joseph L, Colon-Rivera N, New EM, Joseph DM, Hurd JA, Sergott CE, McCullagh EA.   +6 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Quantitative fatty acid signature analysis (QFASA) to explore the diet of the plateau pika (Ochotona curzoniae) during winter on the Qinghai-Xizang (Tibetan) plateau. [PDF]

Oecologia
Li M, Jin Z, Oldakowski L, Ren S, Li B, Li L, Osorio-Mendoza J, Jiao Y, Yong S, Wang D, Zhang Y, Shui G, Speakman JR.   +12 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source