Results 71 to 80 of about 38,424 (214)

The correlation of ASAS Health Index and scales assessing general health status, disease activity, functional capacity, spinal mobility, and quality of life in Turkish patients with ankylosing spondylitis

Gülhane Tıp Dergisi
Aims: We aimed to investigate whether the Assessment of SpondyloArthritis International Society Health Index (ASAS HI) correlates with scales assessing overall health status, disease activity, spinal mobility, quality of life, and functional capacity in ...
Muhammed Canbaş, Hasan Elden, Ece Kaptanoğlu   +2 more
doaj   +1 more source

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

Association of ankylosing spondylitis with cardiovascular disease: a bidirectional two-sample mendelian randomization study

Frontiers in Genetics
BackgroundsCurrent observational investigations hint at a potential linkage between ankylosing spondylitis and cardiovascular wellness. However, the nature of this causality remains to be elucidated.
Pengyu Liu, Juju Shang, Zhi Qi, Shenglei Qiu, Xiaolei Lai, Lixiao Shi, Zhenmin Zhang, Mingxuan Li, Linjing Yang   +8 more
doaj   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis [PDF]

ARP Rheumatology
Aims: Ankylosing spondylitis (AS) is a chronic disease characterized by inflammation of the spine and joints. This study aimed to examine the multifidus (MF) and erector spinae (ES) muscles in AS patients using magnetic resonance imaging (MRI), and to ...
Selçuk Akkaya, Gonca Sağlam Akkaya, Serpil Demirulus, Hanife Baykal Şahin, Gamze Kılıç, Erhan Çapkın, Murat Karkucak   +6 more
doaj  

Causal relationship between gut microbiota and ankylosing spondylitis and potential mediating role of inflammatory cytokines: A mendelian randomization study.

PLoS ONE
Associations between gut microbiota and ankylosing spondylitis have been discovered in previous studies, but whether these associations reflect a causal relationship remains inconclusive. Aiming to reveal the bidirectional causal associations between gut
Xinyu Du, Haibo Li, Hongzhou Zhao, Shuangshuang Cui, Xiaozhuo Sun, Xiaochan Tan   +5 more
doaj   +1 more source

Impact of adalimumab treatment on impairment of non‐professional activities in psoriasis patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Psoriasis can result in reduced quality of life, work productivity loss, and a significant restriction in non‐professional activities. This study investigates the effects of long‐term treatment with adalimumab regarding work ability, non‐professional activities, and health‐related quality of life in a large real‐word ...
Georgios Kokolakis, Sandra Philipp, Thomas Mosch, Björn Fritz, Robert Sabat   +4 more
wiley   +1 more source

Impact of socioeconomic status on disability in a longitudinal rheumatoid arthritis cohort

Internal Medicine Journal, EarlyView.
Abstract The impact of socioeconomic status (SES) on health outcomes in Australians living with rheumatoid arthritis (RA) is not known. We aimed to determine whether differences in disability trajectory were present according to individuals' SES using longitudinal data from the Australian Rheumatology Association Database.
Oscar Russell, Susan Lester, Jessica Stanhope, Rachel J. Black, Marissa Lassere, Claire Barrett, Lyn March, Tom Lynch, Rachelle Buchbinder, Catherine L. Hill   +9 more
wiley   +1 more source

Erectile dysfunction in ankylosing spondylitis patients

International Brazilian Journal of Urology
Background Rheumatic diseases such as ankylosing spondylitis (AS) may be associated with sexual dysfunction. Aim To study erectile function of a group of Brazilian AS patients comparing them with controls.
Thiago Santana, Thelma Skare, Vitor Steil Delboni, Juliana Simione, Ana Paula B. Campos, Renato Nisihara   +5 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source