Results 161 to 170 of about 9,109,837 (237)

Genome-wide association study identifying immune markers in Qingyuan partridge chickens infected with avian Leukosis virus subgroup J

Poultry Science
In poultry, Avian Leukosis Virus (ALV) causes high mortality and significant eradication costs, with no effective vaccines, hindering industry development. Improving resistance to ALV-J offers both economic and ecological value.
Hongwei Jie, Qiong Yin, Wei Liu, Junran Zeng, Hai Xiang, Zheng Ma, Hua Li, Fei Ye   +7 more
doaj   +1 more source

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1783-1798, July 2026.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo, Nagamani Vunnam, Jonathan N. Sachs, Benjamin J. Hackel   +3 more
wiley   +1 more source

An Ankyrin-Based Mechanism for Functional Organization of Dystrophin and Dystroglycan

, 2008
Summaryβ-dystroglycan (DG) and the dystrophin-glycoprotein complex (DGC) are localized at costameres and neuromuscular junctions in the sarcolemma of skeletal muscle.
Ayalon, Gai, Scotland, Paula B., Paula B. Scotland, Gai Ayalon, Davis, Jonathan Q., Jonathan Q. Davis, Vann Bennett, Bennett, Vann   +7 more
core   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Ankyrin-spectrin scaffolds, from blood to brain

, 2006
The initiation and rapid transduction of electrical signals in the nervous system depends on the proper expression of voltage-gated sodium channels in the axon initial segment and nodes of Ranvier. The localization of sodium channel in neurons depends on
Yang, Yang
core  

Detection of Na_v1.5 and ankyrin-G by immunoblot.

, 2013
Relative expression of Nav1.5 (Panel A) and 190 kD ankyrin-G (Panel B) in control (non-infarcted hearts) and post infarct canine epicardial tissue.  Tissues were collected from infarcted hearts (both EBZ and Remote) at post occlusion 24 hr, 48 hr, and 5 ...
Patrick Wright (470353), Thomas J. Hund (256356), Peter J. Mohler (35301), Penelope A. Boyden (256355), Wen Dun (256354), John S. Lowe (470352)   +5 more
core   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Sequence and structural alignments reveal insights into ANKLE2 evolution and function. [PDF]

Protein Sci
Abstract ANKLE2 is an enigmatic protein with emerging roles in cell division, development, and virus replication. While ANKLE2 orthologs are present in all animals, its domain composition has evolved over time. ANKLE2's two namesake domains, the ankyrin repeat and LEM domains (named for LAP2, Emerin, and MAN1), have clear and defined roles; however ...
Fishburn AT, Florio CJ, Skawinski CLS, Becker SS, Holleman E, Robertson AE, Sitchon R, Chédin F, Shah PS.   +8 more
europepmc   +2 more sources

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

Journal of Animal Breeding and Genetics, Volume 143, Issue 4, Page 508-523, July 2026.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez, C. Hervás‐Rivero, R. Rodríguez‐Bermúdez, D. López‐Carbonell, M. Hermida, P. Martínez, L. Varona   +6 more
wiley   +1 more source

Complete telomere-to-telomere genomes uncover virulence evolution conferred by chromosome fusion in oomycete plant pathogens

Nature Communications
Variations in chromosome number are occasionally observed among oomycetes, a group that includes many plant pathogens, but the emergence of such variations and their effects on genome and virulence evolution remain ambiguous.
Zhichao Zhang, Xiaoyi Zhang, Yuan Tian, Liyuan Wang, Jingting Cao, Hui Feng, Kainan Li, Yan Wang, Suomeng Dong, Wenwu Ye, Yuanchao Wang   +10 more
doaj   +1 more source