Results 161 to 170 of about 29,259 (193)

Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons. [PDF]

Dev Cell, 2014
Barry J, Gu Y, Jukkola P, O'Neill B, Gu H, Mohler PJ, Rajamani KT, Gu C.   +7 more
europepmc   +1 more source

Breaking the annotation barrier: An initial subcellular localization atlas of <i>Giardia</i>'s hypothetical and conserved hypothetical proteins provides a resource for functional discovery. [PDF]

Mol Biol Cell
Hagen KD, Zerkle AJ, Arani S, Chase T, Cipriano MJ, Hirakawa MP, Pham JK, Woessner DJ, Nosala C, McInally SG, Hilton NA, Williams JA, Nguyen K, Walker GT, Boghospor L, Tu AB, Bluhm A, Jan S, Chun K, Du G, Sek AC, Booker J, Dawson SC.   +22 more
europepmc   +1 more source

<i>Wolbachia</i> uses ankyrin repeats to target specific fly proteins. [PDF]

mBio
Hamilton W, Hardy E, López-Madrigal S, Phelps M, Martin M, Newton I.   +5 more
europepmc   +1 more source

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Ankyrin(g) ETS domains to DNA

Nature Structural Biology, 1998
The crystal structure of the heterodimeric transcriptional regulator GABPα/β bound to DNA reveals extensive protein–protein interactions between an ETS domain and ankyrin repeats that may influence DNA binding affinity.
Kathryn R. Ely, Ramadurgam Kodandapani
openaire   +1 more source

Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain

Journal of Clinical Neuroscience, 2004
Ankyrin G has recently been shown to be responsible for activation of sodium channels in the developing and regenerating axonal membrane. Via this sodium channel mechanism, elevated ankyrin G levels have been linked with spontaneous ectopic hyperexcitability and thus with pain phenomena in nervous tissue.
Thomas, Kretschmer, Doan H, Nguyen, Roger W, Beuerman, Robert L, Tiel, David G, Kline   +4 more
openaire   +2 more sources

Biochemical and functional characterization of giant ankyrin-G

2021
Ankyrins link diverse ion channels and cell adhesion molecules to the spectrin-based cytoskeleton which stabilizes membranes and regulates physiological processes in various excitable and mechano-resistant tissues and cells. They are regarded as key scaffold proteins at these domains. Three members can be found in vertebrate ankyrin family: ankyrin-R/B/
openaire   +2 more sources

Ankyrin-G Regulates Inactivation Gating of the Neuronal Sodium Channel, Nav1.6

Journal of Neurophysiology, 2006
Ankyrin-G, a modular protein, plays a critical role in clustering voltage-gated sodium channels (Nav channels) in nodes of Ranvier and initial segments of mammalian neurons. However, direct effects of ankyrin-G on electrophysiological properties of Nav channels remain elusive.
Emi, Shirahata, Hirohide, Iwasaki, Masahiro, Takagi, Changqing, Lin, Vann, Bennett, Yasushi, Okamura, Kiyoshi, Hayasaka   +6 more
openaire   +2 more sources

Painful human neuromas: a potential role for a structural transmembrane protein, ankyrin G

Journal of Neurosurgery, 2002
Object. Severe nerve injury induces the formation of a neuroma. Some neuromas cause excruciating pain. Overexpression of Na+ channels leads to hyperexcitability and painful phenomena. Ankyrin G, a multifunctional transmembrane protein of the axolemma, might be a key protein in neuroma formation because it binds Na+ channels in the initial segments of a
Thomas, Kretschmer, Doan H, Nguyen, Roger W, Beuerman, Leo T, Happel, John D, England, Robert L, Tiel, David G, Kline   +6 more
openaire   +2 more sources

Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in bipolar disorder reveals a non‐conservative amino acid change in a short isoform of ankyrin G

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2012
AbstractSignificant association between polymorphisms at the ANK3 gene with bipolar disorder has previously been reported and confirmed in several samples. Here we report on association between ANK3 and bipolar disorder in a new sample of 593 patients and 642 controls (UCL2) as well as the results of sequencing of the exons and flanking regions of ANK3
Alexandra, Dedman, Andrew, McQuillin, Radhika, Kandaswamy, Sally, Sharp, Adebayo, Anjorin, Hugh, Gurling   +5 more
openaire   +2 more sources

Mechanistic studies of ankyrin-B/ankyrin-G autoinhibition and regulation

2015
Ankyrins are a family of scaffold proteins, which serves to link great varieties of functional related but structurally diverse integral membrane proteins to the spectrin-based cytoskeletons. In vertebrates, the Ankyrin family consists of three members: ankyrin-R (AnkR), ankyrin-B (AnkB) and ankyrin-G (AnkG), encoded by ANK1, ANK2 and ANK3 ...
openaire   +2 more sources