Results 51 to 60 of about 68,407 (296)

Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]

, 1997
The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Adams, Aigner, Arber, Arber, Arber, Ashby, Blank, Buckingham, Chevallier, Chien, Chiquet, Chu, Condon, Connor, deLapeyriére, Duxson, Fontaine, Gatchalian, Grayson, Hauschka, Hilfer, Imaizumi-Scherrer, Jellies, Lance-Jones, Lanser, McMahon, Olson, Ontell, Rechsteiner, Ross, Schaeren-Wiemers, Schroeter, Schroeter, Shaw, Sweeney, Tucker, Witzemann, Zou   +37 more
core   +1 more source

Anion transporter: highly cell-type-specific expression of distinct polypeptides and transcripts in erythroid and nonerythroid cells [PDF]

, 1985
Affinity-purified antibodies and cDNA probes specific for the chicken erythrocyte anion transporter (also referred to as band 3) have been used to demonstrate that this protein is expressed in a highly cell- type-specific manner in the avian kidney ...
Cox, John V., Lazarides, Elias, Moon, Randall T.   +2 more
core   +1 more source

Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space [PDF]

, 2013
The notion of energy landscapes provides conceptual tools for understanding the complexities of protein folding and function. Energy Landscape Theory indicates that it is much easier to find sequences that satisfy the "Principle of Minimal Frustration ...
Espada, Rocío, Ferreiro, Diego U., Parra, R. Gonzalo, Sippl, Manfred J., Sánchez, Ignacio E.   +4 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. [PDF]

PLoS ONE, 2007
Here we report the unexpected finding that specific human ANK2 variants represent a new example of balanced human variants. The prevalence of certain ANK2 (encodes ankyrin-B) variants range from 2 percent of European individuals to 8 percent in ...
Peter J Mohler, Jane A Healy, Hui Xue, Annibale A Puca, Crystal F Kline, R Rand Allingham, Evangelia G Kranias, Howard A Rockman, Vann Bennett   +8 more
doaj   +1 more source

A lymphoma plasma membrane-associated protein with ankyrin-like properties. [PDF]

, 1986
In this study we have used several complementary techniques to isolate and characterize a 72-kD polypeptide that is tightly associated with a major mouse T-lymphoma membrane glycoprotein, gp 85 (a wheat germ agglutinin-binding protein), in a 16 S complex.
Balazovich, K, Bourguignon, LY, Suchard, SJ, Walker, G   +3 more
core  

CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]

, 2014
Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
core   +2 more sources

Multifunctional protein: cardiac ankyrin repeat protein [PDF]

Journal of Zhejiang University-SCIENCE B, 2016
Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now.
Na, Zhang, Xiao-Jie, Xie, Jian-An, Wang
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain.

PLoS Biology, 2005
We report identification of an ankyrin-B-based macromolecular complex of Na/K ATPase (alpha 1 and alpha 2 isoforms), Na/Ca exchanger 1, and InsP3 receptor that is localized in cardiomyocyte T-tubules in discrete microdomains distinct from classic ...
Peter J Mohler, Jonathan Q Davis, Vann Bennett   +2 more
doaj   +2 more sources