Results 131 to 140 of about 30,181 (241)
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Spectrins and ankyrin distribution in the glomerulus.
, 2016 ImmunoEM micrographs of spectrin and ankyrin in the glomerulus. Spectrin βΙΙ staining was largely confined to endothelial cells. Spectrin βΙΙΙ was present in both endothelial cells (arrow head) and podocytes (arrow).
Michael C. Stankewich (842238) +4 more
core +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore +6 more
wiley +1 more source
GIT1 enhances neurite outgrowth by stimulating microtubule assembly
Neural Regeneration Research, 2016 GIT1, a G-protein-coupled receptor kinase interacting protein, has been reported to be involved in neurite outgrowth. However, the neurobiological functions of the protein remain unclear.
Yi-sheng Li +6 more
doaj +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, EarlyView.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
, 2014 The formation and retention of distinct membrane domains in the fluidic membrane bilayer is the key process in establishing spatial organization for mediating physiological functions in metazoans.
Tseng, Wei Chou
core
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Background Inherited platelet disorders (IPDs) are rare hematologic conditions encompassing a heterogeneous spectrum of quantitative and qualitative platelet defects, frequently associated with variable clinical phenotypes and comorbidities. Accurate diagnosis necessitates comprehensive genetic characterization, detailed clinical and bleeding ...
Silvia Ferrari +6 more
wiley +1 more source
Development of the G3 Designed ankyrin repeat protein (DARPin) for HER2 imaging
, 2015 Background: Human epidermal growth factor receptor-2 (HER2) expression predicts response to anti-HER2 therapy in breast and gastric cancer. HER2 status is assessed by tumour biopsy but this may not be representative of the larger tumour mass or other ...
Goldstein, RM
core
Mechanical unfolding of an ankyrin repeat protein
, 2010 Ankryin repeat proteins comprise tandem arrays of a 33-residue, predominantly ∞-helical motif that stacks roughly linearly to produce elongated and superhelical structures.
Ltzhaki L. S. +5 more
core +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source