Results 111 to 120 of about 42,872 (270)

Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer

Cancer Science, EarlyView.
YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh, Akihiro Nita, Yudai Ohta, Aya Kobayashi, Hao Li, Yasuhisa Sakamoto, Toshiro Moroishi   +6 more
wiley   +1 more source

The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode [PDF]

, 2005
Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even
, Akman, Alla Lapidus, Altschul, Altschul, Amiri, Anamitra Bhattacharyya, Andersson, Andersson, Aras, Aultman, Balakirev, Bandi, Bandi, Bandi, Bandi, Bandi, Barker, Barton Slatko, Bazzocchi, Bazzocchi, Beard, Besemer, Booth, Bordenstein, Bordenstein, Bosshardt, Bourtzis, Bourtzis, Brattig, Brattig, Brattig, Brayton, Brenot, Campbell, Casiraghi, Casiraghi, Casiraghi, Caturegli, Chirgwin, Chirgwin, Chirgwin, Cloud, Collins, Cross, Curtis, Daubin, den Blaauwen, Dobson, Donald Comb, Dumler, Durvasula, Egyed, Elodie Ghedin, Eugene Goltsman, Eugene Koonin, Ewing, Ewing, Fischer, Flieger, Foster, Francis, Freedman, Genchi, Genchi, Ghedin, Gil, Gordon, Gouin, Grant, Grigoriev, Haarbrink, Haarbrink, Hall, Hise, Hise, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoffman, Hougard, Howell, Ibrahim Kamal, Janos Posfai, Jeng, Jennifer Ware, Jeremy Foster, Jessica Ingram, Jeyaprakash, Jolodar, Kanehisa, Keiser, King, Kira Makarova, Kiryl Tsukerman, Klasson, Kozek, Kozek, Kramer, Kuhn, Kumar, Kurtz, Lamb, Langworthy, Larson, Laurie Moran, Laven, Letunic, Li, Lin, Lin, Lo, Locht, Lowe, MacDonald, Mackenzie, Makarova, Marina Omelchenko, McGuffin, McLaren, Mehul Ganatra, Mikhail Mazur, Mira, Molyneux, Moran, Moran, Moran, Moran, Nancy A. Moran, Narita, Natalia Ivanova, Nielsen, Nikos Kyrpides, O'Neill, Olga Ostrovskaya, Ottesen, Ottesen, Ottesen, Overbeek, Pearlman, Plenge-Bonig, Powell, Powell, Prichard, Prichard, Punkosdy, Rajan, Rao, Rao, Rao, Reader, Richards, Roux, Rubtsov, Saint Andre, Sanjay Kumar, Selkirk, Sexton, Shigenobu, Shiliang Wang, Shukla-Dave, Sinkins, Sinkins, Sinkins, Sironi, Slatko, Slesarev, Smith, Suetsugu, Sun, Tamas, Tamas, Tamas Vincze, Tatusov, Taylor, Taylor, Taylor, Taylor, Taylor, Taylor, Taylor, Townson, van Ham, Vandekerckhove, Victor Joukov, Vinayak Kapatral, Vincent, Warbrick, Ware, Warren, Wernegreen, Wernegreen, Werren, Werren, Werren, Werren, Williams, Wolf, Wu, Zabalou   +204 more
core   +3 more sources

Expanding the Genotype and Phenotype Diversity in a Chinese Cohort With TRPV4‐Related Dysplasia

Clinical Genetics, EarlyView.
Exploring the genotype and phenotype diversity in a Chinese cohort with TRPV4‐related dysplasia. ABSTRACT Dominant mutations in the calcium permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically result in skeletal dysplasia or peripheral neuromuscular disease.
Lina Dong, Kwan Chun Ho, Zhijia Tan, Yanni He, Yapeng Zhou, Shijie Yin, Lin Feng, Janus Siu Him Wong, Michael Kai Tsun To   +8 more
wiley   +1 more source

Interactome of the Autoimmune Risk Protein ANKRD55

Frontiers in Immunology, 2019
The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders.
Nerea Ugidos, Nerea Ugidos, Jorge Mena, Jorge Mena, Sara Baquero, Sara Baquero, Iraide Alloza, Iraide Alloza, Mikel Azkargorta, Felix Elortza, Koen Vandenbroeck, Koen Vandenbroeck, Koen Vandenbroeck   +12 more
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma

Cell Proliferation, EarlyView.
Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the
Sicheng Bian, Jiangxia Cui, Xialin Zhang, Chongzhi Bai, Yanhong Tan, Zhuanghui Hao, Xingpeng Bu, Changxin Qu, Lili Sun, Leilei Lin, Qi Wang, Zhengrui Li, Xufeng Huang, Hengrui Liu, Ruo Wang, Yinghua Li, Hongwei Wang   +16 more
wiley   +1 more source

ASPPs multimerize protein phosphatase 1.

PLoS Genetics
Protein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown.
Derek T Wei, Kayleigh N Morrison, Gwendolyn M Beacham, Erika Beyrent, Cyrus A Habas, Ying Zhang, Laurence Florens, Gunther Hollopeter   +7 more
doaj   +1 more source

Ankyrin repeat and Single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs [PDF]

, 2018
Clear cell Renal Cell Carcinoma (ccRCC) represents the most common kidney cancer worldwide. Increased cell proliferation associated with abnormal microRNA (miRNA) regulation are hallmarks of carcinogenesis.
Fragiadaki, M., Zeidler, M.P.
core   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Enhanced conformational space sampling improves the prediction of chemical shifts in proteins. [PDF]

, 2010
A biased-potential molecular dynamics simulation method, accelerated molecular dynamics (AMD), was combined with the chemical shift prediction algorithm SHIFTX to calculate (1)H(N), (15)N, (13)Calpha, (13)Cbeta, and (13)C' chemical shifts of the ankyrin ...
Abel, Barrett L, Blackledge, Martin, Cervantes, Carla F, Komives, Elizabeth A, Markwick, Phineus RL, McCammon, J Andrew   +5 more
core   +2 more sources