Results 121 to 130 of about 23,098 (204)

The impact of physiological oxidants on triggering amyloid formation of the cell cycle regulator protein p16INK4A

Protein Science, Volume 35, Issue 8, August 2026.
Abstract The tumor suppressor protein p16INK4a plays a key role in cell cycle control and is frequently inactivated in human cancers. We previously discovered that oxidation of its single cysteine residue induces a structural transition from the functional monomeric form into inactive amyloid fibrils.
Briana R. Smith, Nicholas J. Magon, Aakriti Sethi, Shelby G. Gray, Sarah G. Heath, Vanessa K. Morris, Christoph Göbl   +6 more
wiley   +1 more source

Interactive segmentation of membrane and membrane‐mimic densities in cryo‐EM maps

Acta Crystallographica Section D, Volume 82, Issue 8, Page 848-861, August 2026.
SURFER performs automated segmentation of contextual membrane and membrane‐mimic density in cryo‐EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map‐visualization workflows ...
Alok Bharadwaj, Lotte Veerbeek, Arjen Jakobi   +2 more
wiley   +1 more source

Biochemical and Structural Insights into FIH-Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains. [PDF]

Chembiochem, 2023
Saward BG, Leissing TM, Clifton IJ, Tumber A, Timperley CM, Hopkinson RJ, Schofield CJ.   +6 more
europepmc   +1 more source

Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors

Acta Crystallographica Section D, Volume 82, Issue 8, Page 998-1008, August 2026.
Replacement soaking, also known as cross‐soaking, is a compelling method for solving complex structures in cases where traditional soaking and co‐crystallization approaches fail. This method is demonstrated with human tankyrase 2, and new crystal structures of complexes with nanomolar inhibitors and an analogue of the substrate NAD+ are reported ...
Johan Pääkkönen, Sven T. Sowa, Chiara Bosetti, Lari Lehtiö   +3 more
wiley   +1 more source

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1. [PDF]

Nat Commun, 2023
Hori S, Tateyama M, Shirai T, Kubo Y, Saitoh O.   +4 more
europepmc   +1 more source

Optimal 1TEL–target protein linker character is target protein‐dependent. Corrigendum

Acta Crystallographica Section D, Volume 82, Issue 8, Page 1009-1009, August 2026.
The article by Pedroza Romo et al.[(2026), Acta Cryst. D82, 516–532] is corrected.The name of one of the authors in the article by Pedroza Romo et al.[(2026), Acta Cryst. D82, 516–532] is corrected.
Maria J. Pedroza Romo, Alihikaua Keliiliki, Jacob C. Averett, Joseph F. Gonzalez, Ethan Noakes, Elijah W. Wilson, Conrad Smith, Blake Averett, Dalton Hansen, Riley Nickles, Miles Bradford, Sara Soleimani, Tobin Smith, Supeshala Nawarathnage, Prasadika Samarawickrama, Ariel Kelsch, Derick Bunn, Cameron Stewart, Wisdom Abiodun, Evan Tsubaki, Seth Brown, Tzanko I. Doukov, James D. Moody   +22 more
wiley   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4610-4627, August 2026.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. [PDF]

Protein Sci, 2022
Medur Gurushankar MS, Dalvi S, Venkatraman P.   +2 more
europepmc   +1 more source

Dinucleotide repeat polymorphism at the human ankyrin gene (ANK1) [PDF]

Nucleic Acids Research, 1991
M H, Polymeropoulos, D S, Rath, H, Xiao, C R, Merril   +3 more
openaire   +2 more sources

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source