Results 111 to 120 of about 23,098 (204)

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
One thousand nine hundred sixty‐two genes associated with HCC TKI treatment responsiveness were identified through an internal unbiased genome‐wide CRISPR/Cas9 screening. A comprehensive HCC TKI treatment response landscape was constructed by integrating 20 datasets comprising a total of 322 TKI‐treated or TKI‐resistant HCC samples.
Si‐Yu Chen   +10 more
wiley   +1 more source

An Activation-Specific Anti-Mac-1 Designed-Ankyrin-Repeat-Protein Attenuates Colitis in Mice. [PDF]

open access: yesLife (Basel), 2023
Bojti I   +10 more
europepmc   +1 more source

Stress‐Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive ‘Torn Bag Mechanism’ to Exocytosis

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger   +18 more
wiley   +1 more source

Author Correction: Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat. [PDF]

open access: yesNat Commun, 2023
Dong C   +19 more
europepmc   +1 more source

Polymicrobial Extracellular Vesicles Reduce the Innate Immune Response of Human Cystic Fibrosis Bronchial Epithelial Cells

open access: yesJournal of Extracellular Biology, Volume 5, Issue 8, August 2026.
ABSTRACT Chronic antibiotic‐resistant cystic fibrosis (CF) lung infections are the leading cause of death in adults with CF. Despite advances in highly effective modulator therapies, microbial communities persist in the CF lung. The pathogenesis of CF airway infections can be exacerbated by pathogens such as Pseudomonas aeruginosa, which communicates ...
Lily A. Charpentier   +10 more
wiley   +1 more source

Monitoring the Effect of Tributyltin Salicylate and Propionate, Retinoid X Receptor Ligands, on Heat Shock Protein Expression in MDA‐MB‐231 Cells by MALDI MS/MS

open access: yesJournal of Mass Spectrometry, Volume 61, Issue 8, August 2026.
ABSTRACT Organotin (IV) compounds are known to induce apoptosis via the intrinsic mitochondrial pathway, which is a key mechanism of effective anticancer therapy. Their ability to selectively promote apoptotic cell death highlights their potential as chemotherapeutic agents. In this study, the in vitro effects of two triorganotin compounds, tributyltin
Dana Strouhalova   +3 more
wiley   +1 more source

Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model. [PDF]

open access: yesGenes (Basel), 2023
Almosailleakh M   +12 more
europepmc   +1 more source

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