Results 121 to 130 of about 42,872 (270)

Asparagine β-hydroxylation stabilizes the ankyrin repeat domain fold

Mol. BioSyst., 2009
Ankyrin repeats (ARs) are one of the most common structural motifs among eukaryotic proteins. Recent analyses have shown that factor inhibiting hypoxia-inducible factor (FIH) catalyses the hydroxylation of highly conserved Asn-residues within ankyrin repeat domains (ARDs). However, the effect of Asn-hydroxylation on ARD structure is unknown. Supporting
Kelly, L, McDonough, M, Coleman, M, Ratcliffe, P, Schofield, C   +4 more
openaire   +2 more sources

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez, C. Hervás‐Rivero, R. Rodríguez‐Bermúdez, D. López‐Carbonell, M. Hermida, P. Martínez, L. Varona   +6 more
wiley   +1 more source

RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]

, 2014
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S., Spratt, Donald E., Walden, Helen   +2 more
core   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

Frontiers in Cellular Neuroscience, 2015
Shank3 is a postsynaptic scaffolding protein implicated in synapse development and autism spectrum disorders. The Shank3 gene is known to produce diverse splice variants whose functions have not been fully explored.
Jiseok eLee, Changuk eChung, Seungmin eHa, Dongmin eLee, Do-Young eKim, Hyun eKim, Eunjoon eKim, Eunjoon eKim   +7 more
doaj   +1 more source

Data from Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors

, 2023
Ashwini Balakrishnan, Anusha Rajan, Alexander I. Salter, Paula L. Kosasih, Qian Wu, Jenna Voutsinas, Michael C. Jensen, Andreas Plückthun, Stanley R. Riddell   +8 more
openalex   +1 more source

Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell

Molecular Microbiology, EarlyView.
Erythrocyte membrane protein 3 (EMAP3) is a novel Plasmodium berghei protein that is trafficked to the outer membrane surface of the infected red blood cell (iRBC). EMAP3 is not critical for parasite growth or sequestration but offers a new scaffold for displaying Plasmodium falciparum proteins on iRBCs.
Sophia Raine C. Hernandez, Ravish Rashpa, Thorey K. Jonsdottir, Martina S. Paoletta, Josy ter Beek, María Rayón Díaz, Jelte M. M. Krol, Severine Chevalley‐Maurel, Takahiro Ishizaki, Ronnie P.‐A. Berntsson, Chris J. Janse, Blandine Franke‐Fayard, Mathieu Brochet, Ellen S. C. Bushell   +13 more
wiley   +1 more source

Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding

Oral Diseases, EarlyView.
ABSTRACT Objective This observational, cross‐sectional, and analytical study aimed to explore the pathophysiological mechanisms of gingivitis in pregnancy by analyzing the salivary proteomic profile according to gingival bleeding status. Materials and Methods Pregnant women at the 27th week of gestation or beyond were categorized into two groups: those
Gerson Aparecido Foratori‐Junior, Clovis Bergamin Griso, Amanda Borges Pirondi, Laura Teodoro de Marchi, Talita Mendes Oliveira Ventura, Larissa Tercilia Grizzo, Roosevelt da Silva Bastos, Alejandra Chaparro, Nagihan Bostanci, Marília Afonso Rabelo Buzalaf   +9 more
wiley   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Analysis of the Equilibrium and Kinetics of the Ankyrin Repeat Protein Myotrophin

, 2011
We apply the Wako-Saito-Munoz-Eaton model to the study of Myotrophin, a small ankyrin repeat protein, whose folding equilibrium and kinetics have been recently characterized experimentally.
Alessandro Pelizzola, Mauro Faccin, Pierpaolo Bruscolini, Sen S., Taoka M.   +4 more
core   +1 more source