Results 121 to 130 of about 41,338 (239)

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

open access: yesFrontiers in Cellular Neuroscience, 2015
Shank3 is a postsynaptic scaffolding protein implicated in synapse development and autism spectrum disorders. The Shank3 gene is known to produce diverse splice variants whose functions have not been fully explored.
Jiseok eLee   +7 more
doaj   +1 more source

Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding

open access: yesOral Diseases, EarlyView.
ABSTRACT Objective This observational, cross‐sectional, and analytical study aimed to explore the pathophysiological mechanisms of gingivitis in pregnancy by analyzing the salivary proteomic profile according to gingival bleeding status. Materials and Methods Pregnant women at the 27th week of gestation or beyond were categorized into two groups: those
Gerson Aparecido Foratori‐Junior   +9 more
wiley   +1 more source

Biogenesis of the Avian Erythroid Membrane Skeleton : Receptor-mediated Assembly and Stabilization of Ankyrin (Goblin) and Spectrin [PDF]

open access: yes, 1984
Ankyrin is an extrinsic membrane protein in human erythrocytes that links the αß-spectrin-based extrinsic membrane skeleton to the membrane by binding simultaneously to the ß-spectrin subunit and to the transmembrane anion transporter.
Lazarides, Elias, Moon, Randall T.
core  

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer   +2 more
wiley   +1 more source

Ankyrin Repeat:  A Unique Motif Mediating Protein−Protein Interactions

open access: yesBiochemistry, 2006
Ankyrin repeat, one of the most widely existing protein motifs in nature, consists of 30-34 amino acid residues and exclusively functions to mediate protein-protein interactions, some of which are directly involved in the development of human cancer and other diseases.
Junan, Li   +2 more
openaire   +2 more sources

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson   +6 more
wiley   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

A non-canonical ARMS-GABARAP interaction modulates dendritic spine formation and synaptic development

open access: yesThe EMBO Journal
ARMS (ankyrin repeat-rich membrane spanning) is a scaffold protein essential for neurotrophic signaling, synaptic development, and cytoskeletal remodeling.
Wenli Jiang   +9 more
doaj   +1 more source

Identification of resistance sources and genomic regions regulating spot blotch resistance in Asian bread wheat (Triticum aestivum L.) via genome‐wide association study

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Spot blotch (SB), caused by Bipolaris sorokiniana, is a major yield‐limiting disease of wheat (Triticum aestivum L.) in the warm, humid agroclimatic zones of South Asia. The development of resistant cultivars through molecular approaches offers a sustainable strategy for managing this disease.
Nikita Aggarwal   +6 more
wiley   +1 more source

VGLUT1 and PSD‐95 Expression Remains Stable in the Prefrontal and Cerebellar Cortices of the VPA Autism Rat Model

open access: yesDevelopmental Neurobiology, Volume 86, Issue 2, April 2026.
ABSTRACT Autism spectrum disorder (ASD) has recently been described as a synaptopathy where dysregulation at the level of the synapse is thought to evoke an excitation–inhibition (E/I) imbalance implicated in its pathogenesis. The mechanisms through which alterations in glutamatergic signaling bring about an E/I imbalance remain elusive.
Megan Reveley   +4 more
wiley   +1 more source

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