Results 141 to 150 of about 42,872 (270)
Advanced Science, Volume 13, Issue 7, 3 February 2026.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source
Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton +12 more
wiley +1 more source
Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development [PDF]
, 2002 Fadel Tissir +3 more
openalex +1 more source
Genome-wide binding of Multiple ankyrin repeats single KH domain reveals its role in maintenance of gene activation by trithorax group proteins in Drosophila [PDF]
, 2022 Ammad Shaukat +7 more
openalex +1 more source
Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.Various sodium channel isoforms and their scaffolding proteins are found in four different microdomains in vestibular calyx‐bearing afferents. These microdomains serve different purposes, analogous to the heminode, axon initial segment, and synaptic domains of other types of sensory afferents.
Anna Lysakowski +8 more
wiley +1 more source
BMC Plant BiologyBackground High temperatures significantly impair the yield and quality of cotton. Ankyrin-repeat proteins (ANKs) are among the largest superfamilies of proteins in plants and play vital roles in both biotic and abiotic stress responses.
Mengjuan Hou +4 more
doaj +1 more source
United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.ABSTRACT Background Microscopic colitis (MC), comprising lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel disease with increasing incidence. MC etiopathogenesis remains unknown; however, altered colonic epithelial integrity may underlie uncontrolled luminal antigen passage, triggering immuno‐inflammatory responses ...
Danila Guagnozzi +18 more
wiley +1 more source
Specific targeting of human caspases using designed ankyrin repeat proteins [PDF]
, 2017 Caspases play important roles in cell death, differentiation, and proliferation. Due to their high homology, especially of the active site, specific targeting of a particular caspase using substrate analogues is very difficult.
Ackermann, Rafael +5 more
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Protein tandem repeats that produce frameshifts can generate new structural states and functions
The FEBS Journal, Volume 293, Issue 3, Page 842-858, February 2026.We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli +8 more
wiley +1 more source
Altered expression of an ankyrin-repeat protein results in leaf abnormalities, necrotic lesions, and the elaboration of a systemic signal [PDF]
, 2018 Summary: The PR-like proteins, class I β-1,3-glucanase (GLU I) and chitinase (CHN I), are induced as part of a stereotypic response that can provide protection against viral, bacterial, and fungal pathogens.
Arn-Bouldoires, Estelle +5 more
core