Results 141 to 150 of about 41,338 (239)
Expanding the Genotype and Phenotype Diversity in a Chinese Cohort With TRPV4‐Related Dysplasia
Clinical Genetics, Volume 109, Issue 4, Page 796-802, April 2026.Exploring the genotype and phenotype diversity in a Chinese cohort with TRPV4‐related dysplasia. ABSTRACT Dominant mutations in the calcium permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically result in skeletal dysplasia or peripheral neuromuscular disease.
Lina Dong +8 more
wiley +1 more source
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source
Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins. [PDF]
Mol Biol Cell, 2023 Willet AH, Chen JS, Ren L, Gould KL.
europepmc +1 more source
Identification of ceRNA Regulatory Networks Driven by the lncRNA NEAT1 in Multiple Myeloma
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT The lncRNA NEAT1 is overexpressed in multiple myeloma (MM) plasma cells and plays a key role in MM pathogenesis. NEAT1 is involved in ceRNA network in several cancers; however, data in MM are virtually absent. This study identified a NEAT1‐driven ceRNA network involving 96 miRNAs and 40 target genes, selected as concurrently downregulated in ...
Domenica Ronchetti +14 more
wiley +1 more source
Neuronal Scaffold Protein ARMS Interacts with Synaptotagmin-4 C2AB through the Ankyrin Repeat Domain with an Unexpected Mode. [PDF]
Int J Mol Sci, 2023 Zhang F, Chen J, Li Y, Ye J, Wang C.
europepmc +1 more source
Journal of Neurochemistry, Volume 170, Issue 4, April 2026.Cellular and molecular mechanisms contributing to TRPA1‐mediated mechanical and cold hypersensitivity and peripheral neuroinflammation in the reserpine‐induced experimental fibromyalgia model. (1) Macrophage‐originated reactive oxygen species (ROS; purple dots) target the transient receptor potential ankyrin 1 (TRPA1) channel localised in Schwann cells.
Evelyne Silva Brum +7 more
wiley +1 more source
An Activation-Specific Anti-Mac-1 Designed-Ankyrin-Repeat-Protein Attenuates Colitis in Mice. [PDF]
Life (Basel), 2023 Bojti I +10 more
europepmc +1 more source
DNA methylation as a predictor of pituitary neuroendocrine tumour behaviour: A systematic review
Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.Abstract Pituitary neuroendocrine tumours (PitNETs) range from slow‐growing to highly aggressive tumours; however, traditional prognostic markers often fail to predict clinical outcomes reliably. DNA methylation has recently emerged as a promising biomarker for assessing tumour behaviour. This systematic review evaluates its predictive value in PitNETs.
Romy van der Groef +3 more
wiley +1 more source
TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect
iScienceSummary: As ectotherms, insects need heat-sensitive receptors to monitor environmental temperatures and facilitate thermoregulation. We show that TRPA5, a class of ankyrin transient receptor potential (TRP) channels absent in dipteran genomes, may ...
Marjorie A. Liénard +9 more
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 7, Page 3032-3052, 1 April 2026.Abstract figure legend In cortical layer (L)5 pyramidal neurons we found that mitochondria in the axon initial segment (AIS) are distributed non‐uniformly and display robust calcium (Ca2+) uptake during action potential (AP) firing. Because the AIS is the site for the initiation of APs, which are shaped by cytosolic Ca2+ levels, we hypothesized that ...
Koen Kole, Maarten H.P. Kole
wiley +1 more source