Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applications [PDF]
Journal of NanobiotechnologyBackground Targeting both tumor cell surface receptors and soluble pro-angiogenic factors is a promising strategy to improve cancer treatment specificity and reduce therapy resistance.
Feng Chen, Michelle S. Bradbury
doaj +2 more sources
The ankyrin repeat as molecular architecture for protein recognition [PDF]
Protein Science, 2004 AbstractThe ankyrin repeat is one of the most frequently observed amino acid motifs in protein databases. This protein–protein interaction module is involved in a diverse set of cellular functions, and consequently, defects in ankyrin repeat proteins have been found in a number of human diseases.
Leila K, Mosavi +3 more
openaire +4 more sources
Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis [PDF]
BMC BiologyBackground Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4)Â is associated with several neurodevelopmental and neurodegenerative disorders.
Wei Jun Tan +3 more
doaj +2 more sources
Frontiers in Physiology, 2023 Neuronal ankyrin-B is an intracellular scaffolding protein that plays multiple roles in the axon. By contrast, relatively little is known about the function of ankyrin-B in dendrites, where ankyrin-B is also localized in mature neurons.
Julie P. Gupta +2 more
doaj +1 more source
Folding and Stability of Ankyrin Repeats Control Biological Protein Function
Biomolecules, 2021 Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins are involved in protein-protein interaction in order to activate or suppress biological processes. The basic architecture of these proteins comprises repeating
Amit Kumar, Jochen Balbach
doaj +1 more source
The diversity and evolution of Wolbachia ankyrin repeat domain genes. [PDF]
PLoS ONE, 2013 Ankyrin repeat domain-encoding genes are common in the eukaryotic and viral domains of life, but they are rare in bacteria, the exception being a few obligate or facultative intracellular Proteobacteria species.
Stefanos Siozios +5 more
doaj +1 more source
StaRProtein, a web server for prediction of the stability of repeat proteins. [PDF]
PLoS ONE, 2015 Repeat proteins have become increasingly important due to their capability to bind to almost any proteins and the potential as alternative therapy to monoclonal antibodies. In the past decade repeat proteins have been designed to mediate specific protein-
Yongtao Xu, Xu Zhou, Meilan Huang
doaj +1 more source
The push-to-open mechanism of the tethered mechanosensitive ion channel NompC
eLife, 2021 NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to ...
Yang Wang +7 more
doaj +1 more source
Mechanical Anisotropy of Ankyrin Repeats [PDF]
Biophysical Journal, 2012 Red blood cells are frequently deformed and their cytoskeletal proteins such as spectrin and ankyrin-R are repeatedly subjected to mechanical forces. While the mechanics of spectrin was thoroughly investigated in vitro and in vivo, little is known about the mechanical behavior of ankyrin-R.
Lee, W +7 more
openaire +3 more sources
Pakistan Journal of Medicine and Dentistry, 2020 Background: Hepatitis C virus (HCV) is one of the major global causes of death. Different types of gene are involved as Ankyrin repeat domains of RNASE L gene.
Anum Liaquat Ali +3 more
doaj +1 more source