Results 31 to 40 of about 23,098 (204)
Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. [PDF]
PLoS ONE, 2011 The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1 ...
Jon C Aster +9 more
doaj +1 more source
Analysis of the equilibrium and kinetics of the ankyrin repeat protein myotrophin [PDF]
The Journal of Chemical Physics, 2011 We apply the Wako-Saito-Muñoz-Eaton model to the study of myotrophin, a small ankyrin repeat protein, whose folding equilibrium and kinetics have been recently characterized experimentally. The model, which is a native-centric with binary variables, provides a finer microscopic detail than the Ising model that has been recently applied to some ...
Faccin M. +2 more
openaire +4 more sources
Discrete kinetic models from funneled energy landscape simulations. [PDF]
PLoS ONE, 2012 A general method for facilitating the interpretation of computer simulations of protein folding with minimally frustrated energy landscapes is detailed and applied to a designed ankyrin repeat protein (4ANK).
Nicholas P Schafer +5 more
doaj +1 more source
The Contribution of the Ankyrin Repeat Domain of TRPV1 as a Thermal Module [PDF]
Biophysical Journal, 2020 The TRPV1 cation nonselective ion channel plays an essential role in thermosensation and perception of other noxious stimuli. TRPV1 can be activated by low extracellular pH, high temperature, or naturally occurring pungent molecules such as allicin, capsaicin, or resiniferatoxin.
Ernesto, Ladrón-de-Guevara +6 more
openaire +2 more sources
Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.
PLoS Computational Biology, 2013 Ankyrin repeat proteins are elastic materials that unfold and refold sequentially, repeat by repeat, under force. Herein we use atomistic molecular dynamics to compare the mechanical properties of the 7-ankyrin-repeat oncoprotein Gankyrin in isolation ...
Giovanni Settanni +4 more
doaj +1 more source
The PIDDosome: centrosome guardian and backup on the DNA damage response
Molecular & Cellular Oncology, 2021 The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of ...
Matteo Burigotto, Luca L. Fava
doaj +1 more source
Genome-Wide Association Study for Muscle Fat Content and Abdominal Fat Traits in Common Carp (Cyprinus carpio). [PDF]
PLoS ONE, 2016 Muscle fat content is an important phenotypic trait in fish, as it affects the nutritional, technical and sensory qualities of flesh. To identify loci and candidate genes associated with muscle fat content and abdominal fat traits, we performed a genome ...
Xianhu Zheng +5 more
doaj +1 more source
Structural basis of diverse membrane target recognitions by ankyrins
eLife, 2014 Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system ...
Chao Wang +6 more
doaj +1 more source
Designed Ankyrin Repeat Proteins as Scaffolds for Multivalent Recognition [PDF]
Biomacromolecules, 2012 Ankyrin repeat (AR) proteins are composed of tandem repeats of a basic structural motif of ca. 33 amino acid residues that form a β-turn followed by two antiparallel α-helices. Multiple repeats stack together in a modular fashion to form a scaffold that is ideally suited for the presentation of multiple functional groups and/or recognition elements ...
Jessica J, Hollenbeck +4 more
openaire +2 more sources
Nature Communications, 2019 Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.
Bunyarit Meksiriporn +9 more
doaj +1 more source