Results 11 to 20 of about 23,098 (204)

Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask [PDF]

Cell Communication and Signaling
Background Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar, Jyoti Singh, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee   +4 more
doaj   +2 more sources

Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applications [PDF]

Journal of Nanobiotechnology
Background Targeting both tumor cell surface receptors and soluble pro-angiogenic factors is a promising strategy to improve cancer treatment specificity and reduce therapy resistance.
Feng Chen, Michelle S. Bradbury
doaj   +2 more sources

Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation [PDF]

International Journal of Molecular Sciences, 2021
Donald E Spratt, Spratt Donald E
exaly   +2 more sources

Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel NaV1.2 in neurons

Frontiers in Physiology, 2023
Neuronal ankyrin-B is an intracellular scaffolding protein that plays multiple roles in the axon. By contrast, relatively little is known about the function of ankyrin-B in dendrites, where ankyrin-B is also localized in mature neurons.
Julie P. Gupta, Paul M. Jenkins, Paul M. Jenkins   +2 more
doaj   +1 more source

Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs [PDF]

Journal of Biological Chemistry, 2022
Rohan Sakariah Eapen, Johannes Schilling, Amedeo Caflisch   +2 more
exaly   +2 more sources

Folding and Stability of Ankyrin Repeats Control Biological Protein Function

Biomolecules, 2021
Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins are involved in protein-protein interaction in order to activate or suppress biological processes. The basic architecture of these proteins comprises repeating
Amit Kumar, Jochen Balbach
doaj   +1 more source

Mechanical Anisotropy of Ankyrin Repeats [PDF]

Biophysical Journal, 2012
Red blood cells are frequently deformed and their cytoskeletal proteins such as spectrin and ankyrin-R are repeatedly subjected to mechanical forces. While the mechanics of spectrin was thoroughly investigated in vitro and in vivo, little is known about the mechanical behavior of ankyrin-R.
Lee, W, Zeng, X, Rotolo, K, Yang, M, Schofield, C, Bennett, V, Yang, W, Marszalek, P   +7 more
openaire   +3 more sources

StaRProtein, a web server for prediction of the stability of repeat proteins. [PDF]

PLoS ONE, 2015
Repeat proteins have become increasingly important due to their capability to bind to almost any proteins and the potential as alternative therapy to monoclonal antibodies. In the past decade repeat proteins have been designed to mediate specific protein-
Yongtao Xu, Xu Zhou, Meilan Huang
doaj   +1 more source

The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

eLife, 2021
NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to ...
Yang Wang, Yifeng Guo, Guanluan Li, Chunhong Liu, Lei Wang, Aihua Zhang, Zhiqiang Yan, Chen Song   +7 more
doaj   +1 more source

Determination of Ankyrin Repeats Domain (ANK) of RNASE L Gene in Hepatitis C Patients and its effects on Viral Load

Pakistan Journal of Medicine and Dentistry, 2020
Background: Hepatitis C virus (HCV) is one of the major global causes of death. Different types of gene are involved as Ankyrin repeat domains of RNASE L gene.
Anum Liaquat Ali, Syed M. Zahid Azam, Sikandar Ali, Saba Kamil   +3 more
doaj   +1 more source