Identifying tandem Ankyrin repeats in protein structures [PDF]
BMC Bioinformatics, 2014 Tandem repetition of structural motifs in proteins is frequently observed across all forms of life. Topology of repeating unit and its frequency of occurrence are associated to a wide range of structural and functional roles in diverse proteins, and defects in repeat proteins have been associated with a number of diseases.
Chakrabarty, Broto, Parekh, Nita
openaire +2 more sources
Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance. [PDF]
, 2009 Inhibition of nuclear factor kappaB (NF-kappaB) is mainly accomplished by IkappaB alpha, which consists of a signal response sequence at the N-terminus, a six-ankyrin repeat domain (ARD) that binds NF-kappaB, and a C-terminal PEST sequence.
Cervantes, Carla F +5 more
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ConSole: using modularity of contact maps to locate solenoid domains in protein structures. [PDF]
, 2014 BackgroundPeriodic proteins, characterized by the presence of multiple repeats of short motifs, form an interesting and seldom-studied group. Due to often extreme divergence in sequence, detection and analysis of such motifs is performed more reliably on
Godzik, Adam, Hrabe, Thomas
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Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
Nature Communications, 2021 The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles
Nikolas Friedrich +24 more
doaj +1 more source
Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family [PDF]
, 2017 The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible candidate ...
Gasparini, Alessandra +3 more
core +1 more source
Resolving the fine structure in the energy landscapes of repeat proteins
QRB Discovery, 2022 Ankyrin (ANK) repeat proteins are coded by tandem occurrences of patterns with around 33 amino acids. They often mediate protein–protein interactions in a diversity of biological systems.
Murilo N. Sanches +6 more
doaj +1 more source
Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]
, 2006 Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Croall +13 more
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Comparative genome analysis of Wolbachia strain wAu [PDF]
, 2014 BACKGROUND: Wolbachia intracellular bacteria can manipulate the reproduction of their arthropod hosts, including inducing sterility between populations known as cytoplasmic incompatibility (CI). Certain strains have been identified that are unable to
Harris, Simon R. +3 more
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Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. [PDF]
PLoS ONE, 2011 The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1 ...
Jon C Aster +9 more
doaj +1 more source
Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity [PDF]
, 2019 The BARD1 protein, which heterodimerizes with BRCA1, is encoded by a known breast cancer susceptibility gene. While several BARD1 variants have been identified as pathogenic, many more missense variants exist that do not occur frequently enough to assign
Adamovich, Aleksandra I +10 more
core +3 more sources