Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space [PDF]
, 2013 The notion of energy landscapes provides conceptual tools for understanding the complexities of protein folding and function. Energy Landscape Theory indicates that it is much easier to find sequences that satisfy the "Principle of Minimal Frustration ...
Espada, Rocío +4 more
core +2 more sources
PLoS Genetics, 2021 The number of grains per panicle is an important yield-related trait in cereals which depends in part on panicle branching complexity. One component of this complexity is the number of secondary branches per panicle.
Giang Ngan Khong +11 more
doaj +1 more source
Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]
, 2014 BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A +4 more
core +2 more sources
Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.
PLoS Computational Biology, 2013 Ankyrin repeat proteins are elastic materials that unfold and refold sequentially, repeat by repeat, under force. Herein we use atomistic molecular dynamics to compare the mechanical properties of the 7-ankyrin-repeat oncoprotein Gankyrin in isolation ...
Giovanni Settanni +4 more
doaj +1 more source
The PIDDosome: centrosome guardian and backup on the DNA damage response
Molecular & Cellular Oncology, 2021 The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of ...
Matteo Burigotto, Luca L. Fava
doaj +1 more source
Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]
, 1997 The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Adams +37 more
core +3 more sources
Folding of a designed simple ankyrin repeat protein [PDF]
Protein Science, 2004 AbstractAnkyrin repeats (AR) are 33‐residue motifs containing a β‐turn, followed by two α‐helices connected by a loop. AR occur in tandem arrangements and stack side‐by‐side to form elongated domains involved in very different cellular tasks. Recently, consensus libraries of AR repeats were constructed.
V Sathya, Devi +5 more
openaire +2 more sources
Genome-Wide Association Study for Muscle Fat Content and Abdominal Fat Traits in Common Carp (Cyprinus carpio). [PDF]
PLoS ONE, 2016 Muscle fat content is an important phenotypic trait in fish, as it affects the nutritional, technical and sensory qualities of flesh. To identify loci and candidate genes associated with muscle fat content and abdominal fat traits, we performed a genome ...
Xianhu Zheng +5 more
doaj +1 more source
A novel mechanism of RNase L inhibition: Theiler\u27s virus L* protein prevents 2-5A from binding to RNase L [PDF]
, 2018 The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread ...
Drappier, Melissa +8 more
core +4 more sources
Functional diversity of ankyrin repeats in microbial proteins [PDF]
Trends in Microbiology, 2010 The ankyrin repeat (ANK) is the most common protein-protein interaction motif in nature, and is predominantly found in eukaryotic proteins. Genome sequencing of various pathogenic or symbiotic bacteria and eukaryotic viruses has identified numerous genes encoding ANK-containing proteins that are proposed to have been acquired from eukaryotes by ...
Souhaila, Al-Khodor +3 more
openaire +2 more sources