Results 51 to 60 of about 42,872 (270)
The expression of Muscle ankyrin repeat proteins in brown adipose tissue [PDF]
Archives of Biological Sciences, 2011 MARP family members CARP, Ankrd2 and DARP are expressed in the striated muscle, while DARP protein is also detected in brown adipose tissue (BAT). Taking into account recent findings concerning the common origin of muscle and brown fat, expression of ...
Rakićević Ljiljana +3 more
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Notch-regulated Ankyrin Repeat Protein Is Overexpressed in Different Subtypes of Breast Cancer [PDF]
International Journal of Basic Science in Medicine, 2022 Introduction: Breast cancer (BC) is a highly heterogeneous disease that has been classified into several subtypes at the molecular level, each with a distinct outcome. Recently, Notch-regulated ankyrin-repeat protein (NRARP), a gene expressed followed by
Parsa Nazarian +2 more
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Probing Muscle Ankyrin‐Repeat Protein (MARP) Structure and Function [PDF]
The Anatomical Record, 2014 ABSTRACTMuscle ankyrin‐repeat proteins (MARPs) have been shown to serve diverse functions within cardiac and skeletal muscle cells. Apart from their interactions with sarcomeric proteins like titin or myopalladin that locate them along myofilaments, MARPs are able to shuttle to the nucleus where they act as modulators for a variety of transcription ...
Alexander Shiang Lun +2 more
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Structural basis of diverse membrane target recognitions by ankyrins
eLife, 2014 Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system ...
Chao Wang +6 more
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Biological Regulation via Ankyrin Repeat Folding [PDF]
ACS Chemical Biology, 2009 By mimicking the phosphorylation of p19(INK4d), a tumor suppressor containing five ankyrin repeats, the native state could be destabilized to such an extent that only a partially folded state is populated at physiological temperature. This partly folded state, which mimics an on-pathway folding intermediate lacking structure in ankyrin repeats 1 and 2,
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Tandem-repeat protein domains across the tree of life [PDF]
PeerJ, 2015 Tandem-repeat protein domains, composed of repeated units of conserved stretches of 20–40 amino acids, are required for a wide array of biological functions.
Kristin K. Jernigan, Seth R. Bordenstein
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Capturing coevolutionary signals in repeat proteins [PDF]
, 2014 The analysis of correlations of amino acid occurrences in globular proteins has led to the development of statistical tools that can identify native contacts -- portions of the chains that come to close distance in folded structural ensembles.
Espada, Rocío +4 more
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Nature Communications, 2019 Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.
Bunyarit Meksiriporn +9 more
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LRRK2 Structure-Based Activation Mechanism and Pathogenesis
Biomolecules, 2023 Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been identified as a genetic risk factor for both sporadic and familial Parkinson’s disease (PD).
Xiaojuan Zhang, Arjan Kortholt
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Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. [PDF]
, 2012 Protein turnover through cullin-3 is tightly regulated by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link cullin-3 to specific substrates for ubiquitylation.
Chen, Ju +3 more
core +2 more sources