Results 161 to 170 of about 2,018 (241)

Sequence and structural alignments reveal insights into ANKLE2 evolution and function

Protein Science, Volume 35, Issue 6, June 2026.
Abstract ANKLE2 is an enigmatic protein with emerging roles in cell division, development, and virus replication. While ANKLE2 orthologs are present in all animals, its domain composition has evolved over time. ANKLE2's two namesake domains, the ankyrin repeat and LEM domains (named for LAP2, Emerin, and MAN1), have clear and defined roles; however ...
Adam T. Fishburn, Cole J. Florio, Chase L. S. Skawinski, Sydney S. Becker, Ethan Holleman, Avery E. Robertson, Rees Sitchon, Frédéric Chédin, Priya S. Shah   +8 more
wiley   +1 more source

Identification of resistance sources and genomic regions regulating spot blotch resistance in Asian bread wheat (Triticum aestivum L.) via genome‐wide association study

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Spot blotch (SB), caused by Bipolaris sorokiniana, is a major yield‐limiting disease of wheat (Triticum aestivum L.) in the warm, humid agroclimatic zones of South Asia. The development of resistant cultivars through molecular approaches offers a sustainable strategy for managing this disease.
Nikita Aggarwal, Xinyao He, Mukesh Rathore, Farkhandah Jan, Vikas Gupta, Reyazul Rouf Mir, Pawan K. Singh   +6 more
wiley   +1 more source

The role of TRPA1 in lung cancer. [PDF]

Transl Lung Cancer Res
O'Connor D, Finn SP, Gray SG.
europepmc   +1 more source

Spiroplasma Are Protective Heritable Symbionts With Low Physiological Impact in the Drosophilid Fly Zaprionus kolodkinae

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Zaprionus kolodkinae flies carry a maternally inherited ixodetis clade Spiroplasma that protects its host against wasp attack but has low overall physiological impact. Genome analysis presented a set of known symbiosis‐relevant effectors, and one encoding—a ricin B domain protein—that is novel to this Spiroplasma genome.
Nuha Alamer, Stefanos Siozios, Chris Corbin, Emily A. Hornett, Jordan E. Jones, Gregory D. D. Hurst   +5 more
wiley   +1 more source

Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment. [PDF]

Biomolecules
Zhu X, Yu Y, Jiang Z, Otani Y, Fujitani M.   +4 more
europepmc   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Clinical Characteristics and Gene Mutations of Hereditary Spherocytosis in 59 Chinese Children. [PDF]

Mol Genet Genomic Med
Li Y, Wang Y, Liu T, Xiao L, Huang L, Zhang Y, Xiang Y, Yu J.   +7 more
europepmc   +1 more source

Functional Data Strengthen Clinical Validation of PhenoScore Phenotype‐Guided AI for ANKRD11 Missense Variants

Clinical Genetics, Volume 109, Issue 6, Page 1038-1048, June 2026.
PhenoScore, an AI framework integrating facial recognition and clinical phenotype data, accurately identifies pathogenic ANKRD11 missense variants associated with KBG syndrome (AUC 0.95). Validated against functional data, PhenoScore outperforms REVEL and complements AlphaMissense, providing objective phenotypic evidence to reduce variants of uncertain
Evi Andriessen, Elke de Boer, Gholson J. Lyon, Bert B. A. de Vries, Charlotte W. Ockeloen, Alexander J. M. Dingemans   +5 more
wiley   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

In-depth analysis of osmotic gradient ektacytometry parameters across different genotypes in hereditary spherocytosis. [PDF]

Br J Haematol
de Wilde JRA, Kuppens GZL, Boesveld ME, van Vuren AJ, van Solinge WW, Waanders E, van Beers EJ, Rab MAE, Bartels M, van Wijk R.   +9 more
europepmc   +1 more source