Results 181 to 190 of about 172,471 (314)

Study the expression level of Annexin A2 gene in Oviduct Epithelial Cells of Iraqi Cows with Endometritis [PDF]

Mohammed Dhafer Taher, Dhia Hussain Jassim AL-Delemi   +1 more
openalex   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

A semi-automated imaging and analysis pipeline for NET quantification and temporal-profiling of NETosis. [PDF]

Front Immunol
Landry C, Wang L, Gerber E, Holterman CE, Burger D.   +4 more
europepmc   +1 more source

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

Advanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue   +8 more
wiley   +1 more source

Physiological stress improves stem cell modeling of dystrophic cardiomyopathy

Disease Models & Mechanisms
Dominic E. Fullenkamp, Alexander B. Willis, Jodi L. Curtin, Ansel P. Amaral, Kyle T. Dittloff, Sloane I. Harris, Ivana A. Chychula, Cory W. Holgren, Paul W. Burridge, Brenda Russell, Alexis R. Demonbreun, Elizabeth M. McNally   +11 more
doaj   +1 more source

Plasmon-enhanced photocatalytic nanoreactors for selective inactivation of murine leukemia virus (MLV). [PDF]

Nanoscale Adv
Ouyang T, Kundu K, Hood J, Cheng B, Mei Y, Gray A, Gummuluru S, Reinhard BM.   +7 more
europepmc   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Annexins and autoantibodies in autoimmune diseases - Insights into SLE, APS and RA: A review.

Biomol Biomed
Zhou X, Liu J, Wang S, Zhang Y, Xu L, Wu L.   +5 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Annexin 2/Factor Xa–Mediated Signal Transduction [PDF]

, 2008
Salvatore V. Pizzo
openalex   +1 more source