Results 211 to 220 of about 172,471 (314)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Engineered Energy-Harvesting Hybrid Nanoscintillators for Enhanced Cancer Radiotherapy. [PDF]

ACS Appl Mater Interfaces
Secchi V, Villa I, Sala S, Colombo A, Garbujo S, Colombo M, Monguzzi A.   +6 more
europepmc   +1 more source

Characterization of Annexin A1 Glycan Binding Reveals Binding to Highly Sulfated Glycans with Preference for Highly Sulfated Heparan Sulfate and Heparin

, 2011
Tim Horlacher, Christian Noti, José L. de Paz, P. Bindschädler, Marie-Lyn Hecht, David F. Smith, Minoru Fukuda, Peter H. Seeberger   +7 more
openalex   +2 more sources

In Situ Synthesis of a Tumor Microenvironment‐Activated Radiosensitizing Cu2‐xS/LDH Probe for Photoacoustic Imaging‐Guided Radiotherapy

Advanced Science, EarlyView.
We reported a new kind of organic‐inorganic composite nanomaterial with excellent PA imaging performance after the in situ activation by hydrogen sulfide in colorectal cancer tissues, which was used for precise radiotherapy of colorectal cancer. It shows a great application potential for early diagnosis and treatment of tumor.
Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song   +8 more
wiley   +1 more source

The pro‐resolving mediator, annexin A1 regulates blood pressure, and age‐associated changes in cardiovascular function and remodeling [PDF]

Jaideep Singh, Kristy L. Jackson, Feng Tang, Ting Fu, Cameron J. Nowell, Ekaterina Salimova, Helen Kiriazis, Rebecca H. Ritchie, Geoffrey A. Head, Owen L. Woodman, Cheng Xue Qin   +10 more
openalex   +1 more source

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, EarlyView.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

Effect of the cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on <i>in vivo</i> platelet activation, oxidative stress, and procoagulant responses induced by waterpipe smoke exposure in mice. [PDF]

Front Toxicol
Beegam S, Zaaba NE, Elzaki O, Yasin J, Ali BH, Nemmar A.   +5 more
europepmc   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

Characterization of Large Extracellular Vesicles Released by Apoptotic and Pyroptotic Cells. [PDF]

Int J Mol Sci
Khamari D, Fekete N, Tamura R, Khamari R, Kittel A, Nagy B, Menna L, Darula Z, Galinsoga A, Hunyadi-Gulyas E, Bencze M, Buzas EI.   +11 more
europepmc   +1 more source

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source