Results 91 to 100 of about 55,065 (286)
Advanced Healthcare Materials, EarlyView.A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues +6 more
wiley +1 more source
A genome-wide analysis of annexins from parasitic organisms and their vectors
Scientific Reports, 2013 In this study, we conduct an in-depth analysis of annexin proteins from a diverse range of invertebrate taxa, including the major groups that contain the parasites and vector organisms that are harmful to humans and domestic animals.
C. Cantacessi +11 more
semanticscholar +1 more source
Journal of General Virology, 2007 Biochemical studies have suggested that annexin 2 (A2) may participate in cytomegalovirus (CMV) infection. In the current work, effects of A2 monomer (p36) and heterotetramer (A2t; p362p112) were investigated. Demonstrating a role for endogenous A2, the four stages of infection that were followed were each inhibited by anti-p36 or anti-p11 at 37 °C ...
Mélanie C, Derry +4 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini +15 more
wiley +1 more source
Discover PlantsVigna mungo (L.) Hepper, commonly called as black gram is one of the major pulse crop belongs to fabaceae family. Plant annexins are a well-known protein family involved in crucial biological processes such as membrane binding, calcium signalling, and ...
Lipun Sahoo +2 more
doaj +1 more source
Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities
Frontiers in PharmacologyThe Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways.
Mingyang Feng, Yong He, Hui Wang
doaj +1 more source
Advanced Healthcare Materials, EarlyView.We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao +8 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan +9 more
wiley +1 more source
Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin
Molecular Biology of the Cell, 2012 Ectodomain shedding of EGFR ligands by ADAM17 is a key step of transactivation of epidermal growth factor receptor (EGFR) and the downstream signaling network.
Hironao Nakayama +6 more
semanticscholar +1 more source