Results 81 to 90 of about 7,097 (288)

Annexin 2-mediated enhancement of cytomegalovirus infection opposes inhibition by annexin 1 or annexin 5

Journal of General Virology, 2007
Biochemical studies have suggested that annexin 2 (A2) may participate in cytomegalovirus (CMV) infection. In the current work, effects of A2 monomer (p36) and heterotetramer (A2t; p362p112) were investigated. Demonstrating a role for endogenous A2, the four stages of infection that were followed were each inhibited by anti-p36 or anti-p11 at 37 °C ...
Mélanie C, Derry, Michael R, Sutherland, Christina M, Restall, David M, Waisman, Edward L G, Pryzdial   +4 more
openaire   +2 more sources

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Tailored protection against plasmalemmal injury by annexins with different Ca2+ sensitivities

, 2011
The annexins, a family of Ca(2+)- and lipid-binding proteins, are involved in a range of intracellular processes. Recent findings have implicated annexin A1 in the resealing of plasmalemmal injuries.
Katia Monastyrskaya, Luginbühl, Miriam, Draeger, Annette, Eduard B. Babiychuk, Miriam Luginbühl, Hostettler, Andrea, Sarah Potez, Monastyrskaya, Katia, Babiychuk, Eduard B, Andrea Hostettler, Annette Draeger, Potez, Sarah   +11 more
core   +1 more source

The structural properties of full-length annexin A11

Frontiers in Molecular Biosciences
Annexin A11 (ANXA11) is a calcium-dependent phospholipid-binding protein belonging to the annexin protein family and implicated in the neurodegenerative amyotrophic lateral sclerosis.
Erika F. Dudas, Erika F. Dudas, Mark D. Tully, Tamas Foldes, Tamas Foldes, Geoff Kelly, Gian Gaetano Tartaglia, Annalisa Pastore, Annalisa Pastore   +8 more
doaj   +1 more source

[Annexins in mitochondria].

Postepy biochemii, 2016
Annexins form a family of membrane- and calcium-binding proteins, widely distributed in vertebrates. Their interactions with membranes are regulated by changes of intracellular concentration of calcium ([Ca2+]in.), pH, and the presence of negatively charged phospholipids as well as cholesterol in membranes.
Bandorowicz-Pikuła, Joanna, Woś, Marcin, Anna Sekrecka-Belniak, Pikuła, Sławomir   +3 more
openaire   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2

Cell Reports, 2019
Summary: Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC phenotype is an important mechanism for establishing peripheral tolerance to self-antigens.
Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer   +9 more
doaj   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Genome-wide identification and comprehensive analysis of annexin encoding genes in Vigna mungo (L.) Hepper

Discover Plants
Vigna mungo (L.) Hepper, commonly called as black gram is one of the major pulse crop belongs to fabaceae family. Plant annexins are a well-known protein family involved in crucial biological processes such as membrane binding, calcium signalling, and ...
Lipun Sahoo, Bharati Swain, Deepanker Yadav   +2 more
doaj   +1 more source

Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities

Frontiers in Pharmacology
The Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways.
Mingyang Feng, Yong He, Hui Wang
doaj   +1 more source