Results 61 to 70 of about 1,073 (201)

Endothelial cell annexins and oxidative stress [PDF]

, 2000
Annexins are a family of calcium-binding proteins that bind membranes containing negatively charged phospholipids in a calcium-dependent manner. To date 12 human annexins have been identified, many of which are expressed in vascular endothelial cells ...
Sacre, Sandra Michelle
core  

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Biochemical characterisation of parasite annexins

, 2009
No Full ...
Hofmann, Andreas, Osman, Asiah, Paul, Blessy   +2 more
core  

Localization and quantitation of cardiac annexins II, V, and VI in hypertensive guinea pigs

, 1999
Annexins are characterized by Ca2+-dependent binding to phospholipids. Annexin II mainly participates in cell-cell adhesion and signal transduction, whereas annexins V and VI also seem to regulate intracellular calcium cycling.
Pascal Trouvé, Danièle Charlemagne, Ioulia Bélikova, Françoise Marotte, Dmitri Bénévolensky, Jane-Lyse Samuel, Sarah Legot, Françoise Russo-Marie   +7 more
core   +1 more source

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

Sequence logos (weblogo.berkeley.edu) showing amino-acid residue conservation in eukaryotic annexins (upper logo), and bacterial annexins (lower logo).

, 2014
For the bacterial annexins, alignment from Fig. 3 used.
Sławomir Pikuła (509859), Praveen Kumar Kodavali (509858), Krzysztof Pawłowski (183717), Małgorzata Dudkiewicz (183704)   +3 more
core   +1 more source

Zea mays annexins modulate cytosolic free Ca2+ and generate a Ca2+-permeable conductance [PDF]

, 2009
Regulation of reactive oxygen species and cytosolic free calcium ([Ca2+](cyt)) is central to plant function. Annexins are small proteins capable of Ca2+-dependent membrane binding or membrane insertion.
Stancombe, Matthew A, A. Stancombe, Matthew, Battey, N. H., Webb, A. A. R., Miedema, H., Webb, Alex AR, Laohavisit, Anuphon, Mortimer, Jennifer C, Miedema, Henk, Laohavisit, A., Macpherson, Neil, Hofmann, A., Battey, Nicholas H, Brownlee, C., M.Coxon, Laty, Macpherson, N., M. Davies, Julia, Davies, J. M., Hofmann, Andreas, C. Mortimer, Jennifer, H. Battey, Nicholas, Coxon, Katy M, Mortimer, J. C., Stancombe, M. A., Demidchik, Vadim, Demidchik, V., Coxon, K. M., Brownlee, Colin, A.R. Webb, Alex, Davies, Julia M   +29 more
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source