Results 61 to 70 of about 626,524 (297)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Modeling Mist to Annular Flow Development in the Discharge of a Compressor [PDF]
, 2012 A model has been created to describe the development of flow leaving a compressor as it transitions from mist to annular flow. Flow parameters such as the drop size, drop speed, drop concentration, film thickness, and film velocity change as a function ...
Wujek, Scott S., Hrnjak, Predrag S.
core
X-ray diffraction from bone employing annular and semi-annular beams [PDF]
, 2015 This is the final version of the article. Available from the publisher via the DOI in this record.There is a compelling need for accurate, low cost diagnostics to identify osteo-tissues that are associated with a high risk of fracture within an ...
Greenwood, C. +23 more
core +1 more source
Thin plate buckling mitigation and reduction challenges for naval ships [PDF]
, 2013 Thin plate buckling or distortion on ship structures is an ongoing issue for shipbuilders. It has been identified that a significant number of factors can be put in place based on prior knowledge and good practice.
McGhie, W +2 more
core +3 more sources
Dynamic Response of Three-Layered Annular Plate with Imperfections
Studia Geotechnica et Mechanica, 2015 This paper presents the imperfection sensitivity of annular plate with three-layered structure. The plate composed of thin elastic facings and a thicker elastic core is loaded in facing plane.
Pawlus Dorota
doaj +1 more source
Shock and Vibration, 2022 In this investigation, free vibration of stepped circular Mindlin plate with arbitrary boundary conditions is presented by an improved Fourier–Ritz method.
Qingjun Hao, Zhaobo Chen, Wenjie Zhai
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source