Results 121 to 130 of about 2,953 (150)

A Decade-Old Atlas of TMEM (Transmembrane) Protein Family in Lung Cancer: Lessons Learnt and Future Directions. [PDF]

Int J Mol Sci
Zhang S, Cao G, Hu X, Chen C, Chen P.
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Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

Current Topics in Medicinal Chemistry, 2021
ANO1, anoctamin 1(also known as TMEM16A), is the molecular basis of calcium-activated chloride channels with ten transmembrane segments which are widely expressed in mammalian cells, including epithelial cells, vascular smooth muscle tissues, electro-excitatory cells, and some tumor cells.
Xin Cao
exaly   +3 more sources

Anoctamin 1 in secretory epithelia

Cell Calcium, 2014
Fluid and electrolyte releasing from secretory epithelia are elaborately regulated by orchestrated activity of ion channels. The activity of chloride channel at the apical membrane decides on the direction and the rate of secretory fluid and electrolyte.
Yongwoo, Jang, Uhtaek, Oh
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Relationship between TMEM16A/anoctamin 1 and LRRC8A

Pflügers Archiv - European Journal of Physiology, 2016
TMEM16A/anoctamin 1/ANO1 and VRAC/LRRC8 are independent chloride channels activated either by increase in intracellular Ca(2+) or cell swelling, respectively. In previous studies, we observed overlapping properties for both types of channels. (i) TMEM16A/ANO1 and LRRC8 are inhibited by identical compounds, (ii) the volume-regulated anion channel VRAC ...
Roberta, Benedetto, Lalida, Sirianant, Ines, Pankonien, Podchanart, Wanitchakool, Jiraporn, Ousingsawat, Ines, Cabrita, Rainer, Schreiber, Margarida, Amaral, Karl, Kunzelmann   +8 more
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Blockade of anoctamin-1 in injured and uninjured nerves reduces neuropathic pain

Brain Research, 2018
The aim of this study was to determine the participation of anoctamin-1 in 2 models of neuropathic pain in rats (L5/L6 spinal nerve ligation [SNL] and L5 spinal nerve transection [SNT]). SNL and SNT diminished withdrawal threshold in rats. Moreover, SNL up-regulated anoctamin-1 protein expression in injured L5 and uninjured L4 DRG whereas that it ...
Janet Murbartián, Norma Oviedo, Vladimir Allex Martínez Rojas   +2 more
exaly   +3 more sources

Protons inhibit anoctamin 1 by competing with calcium

Cell Calcium, 2015
Cl(-) efflux through Ca(2+)-activated Cl(-) channels (CaCCs) in secretory epithelial cells plays a key role in the regulation of fluid secretion. The fluid and electrolyte secretion is closely related to intracellular pH. CaCCs have been known to be inhibited by intracellular acid.
Hyeyeon, Chun, Hawon, Cho, Jimi, Choi, Jesun, Lee, Sung Min, Kim, Hyungsup, Kim, Uhtaek, Oh   +6 more
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Anoctamin 1 expression in the mouse auditory brainstem

Cell and Tissue Research, 2014
Calcium-activated chloride channels (CaCCs) are involved in numerous physiological functions, including the epithelial movement of fluid. Anoctamin 1 (ANO1) has recently been cloned and characterized as a CaCC and is known to be expressed in various secretory epithelia and in nervous tissues such as the dorsal root ganglia and retina.
Sang Jae, Cho, Ji Hyun, Jeon, Do Ill, Chun, Sang Won, Yeo, In-Beom, Kim   +4 more
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Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte

American Journal of Physiology-Cell Physiology, 2014
Iodide is captured by thyrocytes through the Na+/I− symporter (NIS) before being released into the follicular lumen, where it is oxidized and incorporated into thyroglobulin for the production of thyroid hormones. Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen.
Twyffels, L., Strickaert, A., Virreira, M., Massart, C., Van Sande, J., Wauquier, C., Beauwens, R., Dumont, J. E., Galietta, L. J., Boom, A., Kruys, V.   +10 more
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Altered anoctamin-1 and tyrosine phosphorylation in congenital ureteropelvic junction obstruction

Journal of Pediatric Surgery, 2020
Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis in children. The pathophysiology of UPJ obstruction and the exact mechanism of pelviureteral peristalsis are poorly understood. Anoctamin-1 (ANO1), a Ca2+-activated chloride channel, has been shown to play a key role in muscle wall contractions in the ...
Manuela, Hunziker, Anne-Marie, O'Donnell, Jan, Gosemann, Luis A, Alvarez, Prem, Puri   +4 more
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