Results 21 to 30 of about 2,952 (151)

Design of Anticancer 2,4-Diaminopyrimidines as Novel Anoctamin 1 (ANO1) Ion Channel Blockers [PDF]

Molecules, 2020
Pyrimidine is a privileged scaffold in many synthetic compounds exhibiting diverse pharmacological activities, and is used for therapeutic applications in a broad spectrum of human diseases.
Taewoo Kim, Sinyoung Cho, Haejun Oh, Joonseong Hur, Haedong Kim, Young-Ho Choi, Seongho Jeon, Young Duk Yang, Seok-Ho Kim   +8 more
doaj   +2 more sources

Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1 [PDF]

Communications Biology, 2023
Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun, Yuheng Li, Jianwei Li, Yingjun Tan, Xinxin Yuan, Haoye Meng, Jianting Ye, Guohui Zhong, XiaoYan Jin, Zizhong Liu, Ruikai Du, Wenjuan Xing, Dingsheng Zhao, Jinping Song, Youyou Li, Junjie Pan, Yunzhang Zhao, Qi Li, Aiyuan Wang, Shukuan Ling, Rongji Dai, Yingxian Li   +21 more
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Anoctamin 1 Mediates Thermal Pain as a Heat Sensor [PDF]

Current Neuropharmacology, 2013
Vertebrates can sense and avoid noxious heat that evokes pain. Many thermoTRP channels are associated with temperature sensation. TRPV1 is a representative ion channel that is activated by noxious heat. Anoctamin 1 (ANO1) is a Cl- channel activated by calcium that is highly expressed in small sensory neurons, colocalized with markers for nociceptors ...
Cho, Hawon, Oh, Uhtaek
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Transient Magnetothermal Neuronal Silencing Using the Chloride Channel Anoctamin 1 (TMEM16A) [PDF]

Frontiers in Neuroscience, 2018
Determining the role and necessity of specific neurons in a network calls for precisely timed, reversible removal of these neurons from the circuit via remotely triggered transient silencing.
Rahul Munshi, Shahnaz M. Qadri, Arnd Pralle   +2 more
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Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate gland, a common disease in elderly men. Excessive testosterone is considered to cause BPH. However, its etiologic mechanisms are elusive.
Joo Young, Cha, Jungwon, Wee, Jooyoung, Jung, Yongwoo, Jang, Byeongjun, Lee, Gyu-Sang, Hong, Beom Chul, Chang, Yoon-La, Choi, Young Kee, Shin, Hye-Young, Min, Ho-Young, Lee, Tae-Young, Na, Mi-Ock, Lee, Uhtaek, Oh   +13 more
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Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 [PDF]

Frontiers in Pharmacology
Colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC, in particular,
Yohan Seo, Yohan Seo, Sion Lee, Raju Das, Sung Baek Jeong, Chul Soon Park, Minuk Kim, Deok Kyu Yoon, Armin Sultana, Kantu Das, Jae-Eon Lee, Yong Hyun Jeon, Phan Thi Thanh Huong, Nguyen Xuan Nhiem, Joohan Woo, Joohan Woo   +15 more
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Attenuation of Ampullary Anoctamin 1 by the peritoneal fluid in rhesus macaques with spontaneous endometriosis [PDF]

Biology of Reproduction
Abstract Altered peristaltic and ciliary dysfunction is a feature of females with endometriosis. To further explore this premise, we examined the ampulla of rhesus macaques (Macaca mulatta) with and without spontaneous endometriosis for the expression of adenylate kinase 7 (AK7), a mitochondrial-dwelling nucleotide converting enzyme with
Luo, Fangzhou, Slayden, Ov
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Direct repression of anoctamin 1 ( ANO1 ) gene transcription by Gli proteins [PDF]

The FASEB Journal, 2019
ABSTRACT The Ca 2+ ‐activated Cl − channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development. The human
Amelia, Mazzone, Simon J, Gibbons, Seth T, Eisenman, Peter R, Strege, Tenghao, Zheng, Mauro, D'Amato, Tamas, Ordog, Martin E, Fernandez-Zapico, Gianrico, Farrugia   +8 more
openaire   +3 more sources

Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands [PDF]

Heliyon, 2019
Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well.
Ryouichi Satou, Yoshiyuki Shibukawa, Maki Kimura, Naoki Sugihara   +3 more
doaj   +2 more sources

Role of Anoctamin-1 and Bestrophin-1 in Spinal Nerve Ligation-Induced Neuropathic Pain in Rats [PDF]

Molecular Pain, 2015
Background Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies suggest that CaCCs family members
Jorge Baruch Pineda-Farias, Paulino Barragan-Iglesias, Emanuel Loeza-Alcocer, Jorge E Torres-Lopez, Héctor Isaac Rocha-Gonzalez, Francisca Perez-Severiano, Rodolfo Delgado-Lezama, Vinicio Granados-Soto   +7 more
doaj   +2 more sources