Results 51 to 60 of about 2,952 (151)

Effects of protein diet on expression of Anoctamin1 of Cajal cell in the nervous plexus of the stomach in male mice

Journal of the Pakistan Medical Association
Objective: To determine the association between a protein-rich diet and the expression of anoctamin 1 in Interstitial cells of Cajal within the muscle layer of the stomach wall in male mice.
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hiba Majed Rasol   +2 more
doaj   +1 more source

Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Acta Pharmaceutica Sinica B, 2021
Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu   +11 more
doaj   +1 more source

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Nature Communications, 2019
The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells.
Anamika Dayal, Shu Fun J. Ng, Manfred Grabner   +2 more
doaj   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Structure-Function Analysis of the Anion-Selective Pore of Anoctamin-1 [PDF]

Biophysical Journal, 2011
The anoctamins are a newly described family of anion channels. It has been proposed that anoctamin-1 (Ano1) has 8 transmembrane segments (TMDs) with a re-entrant loop between the 5th and 6th TMD that participates in forming the selectivity filter. To clarify the detailed structure and function of this region, we used cysteine accessibility scanning ...
Yu, Kuai, Cui, Yuanyuan, Hartzell, H. Criss   +2 more
openaire   +1 more source

Ano1 is a Prognostic Biomarker That is Correlated with Immune Infiltration in Colorectal Cancer

International Journal of General Medicine, 2022
Jun Chen,1,* Hongli Wang,2,* Fang Peng,3,* Haiyan Qiao,1 Linfeng Liu,1 Liang Wang,1 Bingbing Shang4 1Laboratory Animal Center, Dalian Medical University, Dalian, 116044, Liaoning Province, People’s Republic of China; 2Cardiology Department ...
Chen J, Wang H, Peng F, Qiao H, Liu L, Wang L, Shang B   +6 more
doaj  

ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers

Frontiers in Pharmacology, 2023
Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park, Raju Das, Nguyen Xuan Nhiem, Nguyen Xuan Nhiem, Sung Baek Jeong, Minuk Kim, Dongguk Kim, Hye In Oh, Su-Hyeon Cho, Oh-Bin Kwon, Jae-Hyeog Choi, Chul Soon Park, Song-Rae Kim, Uk Yeol Moon, Boksik Cha, Dong Kyu Choi, Sungwoo Lee, Wan Namkung, Joohan Woo, Joohan Woo, Yohan Seo   +20 more
doaj   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Anoctamin‐1 is expressed and functional in the Pulmonary Vascular Endothelium

The FASEB Journal, 2013
Background and Objective The expression and functional role of Anoctamin‐1 (ANO1), a Ca2+ activated Cl channel in the endothelial cells (EC) is unclear. We sought to confirm the presence of ANO1 in the pulmonary vascular EC (PVEC) and the effect of ANO1 activation on EC membrane potential (Vm).
Ayed Mamdouh Allawzi, Alexander Vang, Anlong Li, Gaurav Choudhary   +3 more
openaire   +1 more source

A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca2+-activated Cl− current when transfected into HEK293

BMC Neuroscience, 2017
Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dependent Ca2+-activated Cl ...
Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo, Juan Bacigalupo   +4 more
doaj   +1 more source