Anoctamin-1 in the juvenile rat urinary bladder. [PDF]
PLoS ONE, 2014 PURPOSE: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. MATERIALS AND METHODS: Bladders from 3 week old Wistar rats were studied.
Dominika A Bijos +2 more
doaj +6 more sources
Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers [PDF]
Frontiers in ImmunologyGastrointestinal (GI) cancers are main causes of poor health, with most remaining difficult to treat effectively. Identifying new targets for treatment is crucial for improving the efficacy of tumour therapies and enhancing patient quality of life ...
Xiaoyue Zhang +6 more
doaj +4 more sources
The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases [PDF]
Frontiers in Cardiovascular MedicineCardiocerebral vascular disease has long been the leading cause of morbidity and mortality worldwide. Although there are many effective avenues for preventing and treating cardiocerebral vascular disease, further research is still needed to identify more
Jia-qi Zhang +6 more
doaj +4 more sources
Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity [PDF]
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
doaj +5 more sources
Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells [PDF]
Animal Cells and Systems, 2019 Anaplastic thyroid carcinoma (ATC) is a rare malignancy with very poor prognosis. The exact cause underlying its strong aggressive nature is not clear.
Jae-Young Kim +7 more
doaj +4 more sources
Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans [PDF]
Nature CommunicationsMechanotransduction channels are widely expressed in both vertebrates and invertebrates, mediating various physiological processes such as touch, hearing and blood-pressure sensing.
Wenjuan Zou +16 more
doaj +4 more sources
The role of anoctamin 1 in liver disease [PDF]
Journal of Cellular and Molecular MedicineAbstractLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the ...
Xin Li +6 more
openaire +3 more sources
Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction [PDF]
Nature Communications, 2022 Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.
Weijia Sun +21 more
doaj +2 more sources
Interaction between thermosensitive TRP channels and anoctamin 1 [PDF]
The Journal of Physiological SciencesSome thermosensitive transient receptor potential (TRP) channels form a protein complex with anoctamin 1 (ANO1, also called TMEM16A). TRP channels have high calcium permeability, and the calcium entering cells through TRP channel activation activates ANO1, a calcium-activated chloride channel, involved in many physiological and pathological conditions.
Takayama Y.
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Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract [PDF]
Pflügers Archiv - European Journal of Physiology, 2023 AbstractInflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide and ivermectin, are intensively discussed for the treatment of viral inflammatory airway infections.
Ousingsawat, Jiraporn +3 more
openaire +4 more sources