Results 71 to 80 of about 2,952 (151)

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Histological and histochemical study of effect of dietary fibre in motility of stomach in male mice

Journal of the Pakistan Medical Association
Objective: To investigate the relationship between dietary fibres and muscularis externa layer. Method: The experimental study was conducted at the Anatomy Department of the College of Medicine, Al- Nahrain University, Iraq, from November 2020 to April ...
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hussein Abbas Jarullah   +2 more
doaj   +1 more source

TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation

Biomedicine & Pharmacotherapy, 2020
Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment of coronary spasmodic disorders.TMEM16A-encoded anoctamin 1 (ANO1), a Ca2+ activated Cl- channel ...
Guijin, Ma, Jiangtao, Zhang, Xiaomin, Yang, Pengmei, Guo, Xiaomin, Hou, Yanying, Fan, Yu, Liu, Mingsheng, Zhang   +7 more
openaire   +2 more sources

Calcium- and Voltage-Dependent Dual Gating ANO1 is an Intrinsic Determinant of Repolarization in Rod Bipolar Cells of the Mouse Retina

Cells, 2020
TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik, Yong Soo Park, In-Beom Kim   +2 more
doaj   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]

PLoS ONE, 2015
The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo, Jinhong Park, Minseo Kim, Ho K Lee, Jin-Hee Kim, Jin-Hyun Jeong, Wan Namkung   +6 more
doaj   +1 more source

Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu, Usri H. Ibrahim, Irene Mackraj, Carola Niesler   +3 more
wiley   +1 more source

Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Cystic fibrosis (CF) airway epithelium is constantly subjected to injury events due to chronic infection and inflammation. Moreover, abnormalities in CF airway epithelium repair have been described and contribute to the lung function decline seen in CF patients. In the last past years, it has been proposed that anoctamin 1 (ANO1), a Ca(2+)-activated Cl(
Ruffin, Manon, Voland, Mélanie, Marie, Solenne, Bonora, Monique, Blanchard, Elise, Blouquit-Laye, Sabine, Naline, Emmanuel, Puyo, Philippe, Le Rouzic, Philippe, Guillot, Loic, Corvol, Harriet, Clement, Annick, Tabary, Olivier   +12 more
openaire   +4 more sources

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Frontiers in Pharmacology, 2019
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto   +8 more
doaj   +1 more source

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

Molecular Cancer, 2017
TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang, Liang Zou, Ke Ma, Jiankun Yu, Huizhe Wu, Minjie Wei, Qinghuan Xiao   +6 more
doaj   +1 more source