Results 41 to 50 of about 107,476,558 (181)

Disulfide Bond Connectivity and Oligomeric State of Anoctamin-1 [PDF]

Biophysical Journal, 2013
TMEM16A(a)/anoctamin-1 (Ano1) has been identified as a Ca-activated chloride channel. Using blue native PAGE, SDS-PAGE and chemical cross-linking, we have shown that the mouse Ano1 channel (mAno1) shares an obligate homodimeric architecture with the hCLC-1 channel (Fallah et al. Molecular & Cellular Proteomics 10.1074/mcp. M110.004697, 2011).
Schmalzing, Gunther, Detro-Dassen, Silvia, Braam, Ursula, Klapperstueck, Manuela, Markwardt, Fritz   +4 more
openaire   +1 more source

Presence of the Ca2+-activated chloride channel anoctamin 1 in the urethra and its role in excitatory neurotransmission

, 2012
We investigated the cellular distribution of the calcium-activated chloride channel (CaCC), anoctamin 1, in the urethra of mice, rats, and sheep by both immunofluorescence and PCR. We studied its role in urethral contractility by examining the effects of
Sancho González, María, Triguero Robles, Domingo, García Pascual, María De Los Ángeles   +2 more
core   +2 more sources

Chloride – The Underrated Ion in Nociceptors

Frontiers in Neuroscience, 2020
In contrast to pain processing neurons in the spinal cord, where the importance of chloride conductances is already well established, chloride homeostasis in primary afferent neurons has received less attention.
Bettina U. Wilke, Kai K. Kummer, Michael G. Leitner, Michaela Kress   +3 more
doaj   +1 more source

Validation of splice altering morpholino knockdown of anoctamin 1 [PDF]

, 2015
Morpholino oligonucleotides (MO) are commonly used to reduce gene expression. MO selectivity is determined by selection of a unique oligonucleotide sequence in the target of interest Suitable targets for splice altering MO are at an intron-exon ...
Denora, Maxwell
core   +2 more sources

Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line

Stem Cell Research, 2022
The Transmembrane member 16A (TMEM16A), also known as anoctamin-1 (ANO1), is a calcium-activated chloride channel present in the airway epithelium. It is known to be involved in the apical chloride secretion indicating that TMEM16A could be addressed for
Mark-Christian Jaboreck, Jonathan Lukas Lühmann, Mia Mielenz, Frauke Stanke, Gudrun Göhring, Ulrich Martin, Ruth Olmer, Sylvia Merkert   +7 more
doaj   +1 more source

Anoctamin-1 is induced by TGF-β and contributes to lung myofibroblast differentiation.

Am J Physiol Lung Cell Mol Physiol
This study describes a novel mechanism of differentiation of human lung fibroblasts (HLFs) to myofibroblasts: the key process in the pathogenesis of pulmonary fibrosis. Transforming growth factor-β (TGF-β) drives the expression of calcium-activated chloride channel anoctmin-1 (ANO1) leading to an increase in intracellular levels of chloride. The latter
Reed EB, Orbeta S, Miao BA, Sitikov A, Chen B, Levitan I, Solway J, Mutlu GM, Fang Y, Mongin AA, Dulin NO.   +10 more
europepmc   +3 more sources

Novel mutations in the anoctamin 5 gene ( ANO5 ) associated with limb‐girdle muscular dystrophy 2L [PDF]

, 2013
Introduction: We present a Jordanian man with the typical LGMD 2L phenotype of early, asymmetric quadriceps weakness and subsequent biceps brachii weakness. Methods: Case report.
Little, Ann A., Mckeever, Paul E., Gruis, Kirsten L.   +2 more
core   +1 more source

Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins. [PDF]

FASEB J, 2019
ABSTRACT The Ca 2+ ‐activated Cl − channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development. The human
Mazzone A, Gibbons SJ, Eisenman ST, Strege PR, Zheng T, D'Amato M, Ordog T, Fernandez-Zapico ME, Farrugia G.   +8 more
europepmc   +3 more sources

Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. [PDF]

PLoS ONE, 2013
Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(
Ji Hyun Jeon, Sun Sook Paik, Myung-Hoon Chun, Uhtaek Oh, In-Beom Kim   +4 more
doaj   +1 more source

Analyse von Topologie und Assemblierungsverhalten der Calcium-aktivierten Chloridkanäle Anoctamin-1, -2, -5, -6, -9 und -10

, 2023
Ca2+-activated Cl- Channels (CaCCs) are expressed in numerous tissues where they play an important role in physiological processes including epithelial electrolyte secretion or vascular smooth muscle contraction.
Panning, Anna-Carina Elisabeth
core