Results 61 to 70 of about 133 (88)

Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux

Cellular Physiology and Biochemistry, 2014
Background/Aims: Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified.
Carmela Iosco, Cristina Cosentino, Laura Sirna, Roberta Romano, Silvia Cursano, Alessandra Mongia, Giampaolo Pompeo, Julie di Bernardo, Claudio Ceccarelli, Giovanni Tallini, Kerry J. Rhoden   +10 more
doaj   +1 more source

Control of Ion Transport by Tmem16a Expressed in Murine Intestine

Frontiers in Physiology, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann, Raquel Centeio, Podchanart Wanitchakool, Inês Cabrita, Roberta Benedetto, Tultul Saha, Kazi Mirajul Hoque, Kazi Mirajul Hoque, Rainer Schreiber   +8 more
doaj   +1 more source

Temporal Expression Patterns of Clock Genes and Aquaporin 5/Anoctamin 1 in Rat Submandibular Gland Cells

Frontiers in Physiology, 2017
Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues.
Ryouichi Satou, Masaki Sato, Maki Kimura, Yoichi Ishizuka, Masakazu Tazaki, Naoki Sugihara, Yoshiyuki Shibukawa   +6 more
doaj   +1 more source

High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma

Scientific Reports
Human papilloma virus-negative head and neck squamous cell carcinoma (HNSCC) frequently harbors 11q13 amplifications. Among the oncogenes at this locus, CCND1 and ANO1 are linked to poor prognosis; however, their individual roles in treatment resistance ...
Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer   +5 more
doaj   +1 more source

How Epstein–Barr Virus Drives Multiple Sclerosis: New Mechanisms and Therapeutic Lessons

MedComm, Volume 7, Issue 7, July 2026.
Dan Liu, Wenhui Fan, Pengtao Jiao
wiley   +1 more source

Highlights for the 6th International Ion Channel Conference: ion channel structure, function, disease and therapeutics

Acta Pharmaceutica Sinica B, 2017
To foster communication and interactions amongst international scholars and scientists in the field of ion channel research, the 6th International Ion Channel Conference (IICC-2017) was held between June 23–27, 2017 in the eastern coastal city of Qingdao,
Limei Wang, Kewei Wang
doaj   +1 more source

Anoctamin-1 Cl Channels in Nociception: Activation by an -Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01

Molecular Pain, 2015
Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
doaj   +1 more source

ER stress-induced ITPR1/ANO1 signaling drives trigeminal neuropathic pain through calcium-dependent neuronal hyperexcitability

The Journal of Headache and Pain
Background Endoplasmic reticulum (ER) stress has been implicated in various chronic pain conditions, but its role in trigeminal neuropathic pain (TNP) remains unclear.
Huan-Jun Lu, Jia-Wen Shen, Ning-Yi Ren, Nan Hu, Jian-Ke Cen, Meng-Xuan Huang, Si-Yuan Song, Ling-Jie Ma, Xiao-Bo Wu, Xia Li, Mei-Xian Li, Hao Wu, Gyu-Sang Hong, Uhtaek Oh, Yong-Jing Gao   +14 more
doaj   +1 more source

Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential

Frontiers in Pharmacology
Background: Prostate cancer and non-small cell lung cancer (NSCLC) present significant challenges in the development of effective therapeutic strategies.
Yohan Seo, Sion Lee, Minuk Kim, Dongguk Kim, Sung Baek Jeong, Raju Das, Armin Sultana, SeonJu Park, Nguyen Xuan Nhiem, Phan Thi Thanh Huong, Oh-Bin Kwon, Wan Namkung, Joohan Woo, Joohan Woo   +13 more
doaj   +1 more source

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Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

Current Topics in Medicinal Chemistry, 2021
Bing Niu, Xiaosheng Qu, Xin Cao
exaly