Results 71 to 80 of about 107,476,558 (181)

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells

, 2014
Polycystic kidney diseases are characterized by multiple bilateral renal cysts that gradually enlarge and lead to a decline in renal function. Cyst enlargement is driven by transepithelial chloride secretion, stimulated by enhanced levels of cyclic ...
Faria, Diana, Kunzelmann, Karl, Schreiber, Rainer, Eckardt, Kai-Uwe, Buchholz, Bjoern, Schley, Gunnar   +5 more
core   +1 more source

Thermo‐tone: A newly revealed mechanism of blood flow regulation

Experimental Physiology, EarlyView.
Abstract Myogenic tone enables dynamic control of tissue blood flow. This intrinsic property of vascular smooth muscle cells to sense stretch and reflexively adjust the calibre of small arteries is crucial to maintain capillary pressure and a blood flow reserve. For over 120 years blood pressure was considered the sole determinant of myogenic tone. Our
Thieu X. Phan, Gerard P. Ahern
wiley   +1 more source

TMEM16A(a)/anoctamin-1 Shares a Homodimeric Architecture with CLC Chloride Channels

Molecular & Cellular Proteomics, 2011
TMEM16A/anoctamin-1 has been identified as a protein with the classic properties of a Ca(2+)-activated chloride channel. Here, we used blue native polyacrylamide gel electrophoresis (BN-PAGE) and chemical cross-linking to assess the quaternary structure of the mouse TMEM16A(a) and TMEM16A(ac) splice variants as well as a genetically concatenated ...
Fallah, Ghada, Römer, Thomas, Detro-Dassen, Silvia, Braam, Ursula, Markwardt, Fritz, Schmalzing, Günther   +5 more
openaire   +2 more sources

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels

, 2011
The Ca(2+)-activated Cl(-) channels (CaCCs) are involved in a variety of physiological functions, such as transepithelial anion transport, smooth muscle contraction and olfaction.
Ferrera L., Paolo Scudieri, Loretta Ferrera, Sondo E., Scudieri, Paolo, Ferrera, Loretta, Luis J. V. Galietta, Galietta, Luis J. V., Scudieri P., Galietta L. J. V., Elvira Sondo, Sondo, Elvira   +11 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Anoctamin 1 and c-Kit immunohistochemical study of interstitial cells of Cajal in the muscularis externa of human gastrointestinal tract

Folia Morphologica, 2023
BACKGROUND: Interstitial cells of Cajal (ICC) are widely distributed in human gastrointestinal (GI) tract, especially in the layer of muscularis externa between neurons and smooth muscles.
A. Al-Ahmadi, R. A. Mohammed, M. Atteya, T. A. Al-Matrafi, M. A. Alfayez   +4 more
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation

, 2023
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs and resulting in deterioration in lung function. Transforming growth factor-beta (TGF-β) is one of the most established drivers of fibrotic processes.
Eleanor B. Reed, Shaina Orbeta, Bernadette A. Miao, Albert Sitikov, Bohao Chen, Irena Levitan, Julian Solway, Gökhan M. Mutlu, Yun Fang, Alexander A. Mongin, Nickolai O. Dulin   +10 more
openaire   +2 more sources

Rhabdomyolysis as an uncommon manifestation of anoctamin-5 muscular dystrophy [PDF]

Background: Anoctamin-5 (ANO5) muscular dystrophy is a rare neuromuscular disease. Muscular weakness and impaired gait may be evident at the moment of diagnosis, serving as defining characteristics of additional muscular dystrophies.
Marta Rodrigues, Tiago Dias da Costa, António Mateus-Pinheiro, Sónia Moreira   +3 more
core   +1 more source

Histological and histochemical study of effect of dietary fibre in motility of stomach in male mice

Journal of the Pakistan Medical Association
Objective: To investigate the relationship between dietary fibres and muscularis externa layer. Method: The experimental study was conducted at the Anatomy Department of the College of Medicine, Al- Nahrain University, Iraq, from November 2020 to April ...
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hussein Abbas Jarullah   +2 more
doaj   +1 more source