Results 111 to 120 of about 123,298,984 (178)

Evaluating the molecular function of zebrafish Anoctamin 1a

microPublication Biology
Calcium-activated chloride channels (CaCCs) regulate key physiological processes like epithelial secretion, sensory transduction, gastrointestinal pacemaking, and muscle contraction.
Amanda Dimatteo, Nicole Stango, Adam Rich, Tara Sweet   +3 more
doaj   +1 more source

Control of Ion Transport by Tmem16a Expressed in Murine Intestine

Frontiers in Physiology, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann, Raquel Centeio, Podchanart Wanitchakool, Inês Cabrita, Roberta Benedetto, Tultul Saha, Kazi Mirajul Hoque, Kazi Mirajul Hoque, Rainer Schreiber   +8 more
doaj   +1 more source

High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma

Scientific Reports
Human papilloma virus-negative head and neck squamous cell carcinoma (HNSCC) frequently harbors 11q13 amplifications. Among the oncogenes at this locus, CCND1 and ANO1 are linked to poor prognosis; however, their individual roles in treatment resistance ...
Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer   +5 more
doaj   +1 more source

Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex. [PDF]

, 2015
Calcium-activated chloride channels of the anoctamin (alias TMEM16) protein family fulfill critical functions in epithelial fluid transport, smooth muscle contraction and sensory signal processing.
Daniel Parthier, Stephan Frings, Weiping Zhang, Frank Möhrlen, Steffen Schmelzeisen   +4 more
core   +1 more source

The Activation and Biophysical Properties of Anoctamin 8 [PDF]

, 2018
학위논문 (석사)-- 서울대학교 대학원 : 융합과학기술대학원 분자의학 및 바이오제약학과, 2018. 8. 신영기, 오우택.ANO8 is a member of the Anoctamin/TMEM16 family which was previously defined as a superfamily of calcium-activated chloride channels after the identification of ANO1.
박세라
core  

Bioinformatic Characterization of the Anoctamin Family of Calcium-Activated Chloride Channels and the Establishment of Homology Using Protein Sequence Analysis [PDF]

, 2015
The Anoctamin Family of proteins is closely related to both Transmembrane Channel-like proteins and DUF221 proteins who's functions are largely unknown. These three families are grouped into a larger superfamily called the Anoctamin Superfamily. Here, we
McLaughlin, Daniel
core  

Anoctamin 1 antagonism potentiates conventional tocolytic-mediated relaxation of pregnant human uterine smooth muscle. [PDF]

J Physiol Sci, 2021
Hyuga S, Parry RC, Danielsson J, Vink J, Fu XW, Wu A, Dan W, Yim PD, Gallos G.   +8 more
europepmc   +1 more source

ER stress-induced ITPR1/ANO1 signaling drives trigeminal neuropathic pain through calcium-dependent neuronal hyperexcitability

The Journal of Headache and Pain
Background Endoplasmic reticulum (ER) stress has been implicated in various chronic pain conditions, but its role in trigeminal neuropathic pain (TNP) remains unclear.
Huan-Jun Lu, Jia-Wen Shen, Ning-Yi Ren, Nan Hu, Jian-Ke Cen, Meng-Xuan Huang, Si-Yuan Song, Ling-Jie Ma, Xiao-Bo Wu, Xia Li, Mei-Xian Li, Hao Wu, Gyu-Sang Hong, Uhtaek Oh, Yong-Jing Gao   +14 more
doaj   +1 more source

Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential

Frontiers in Pharmacology
Background: Prostate cancer and non-small cell lung cancer (NSCLC) present significant challenges in the development of effective therapeutic strategies.
Yohan Seo, Sion Lee, Minuk Kim, Dongguk Kim, Sung Baek Jeong, Raju Das, Armin Sultana, SeonJu Park, Nguyen Xuan Nhiem, Phan Thi Thanh Huong, Oh-Bin Kwon, Wan Namkung, Joohan Woo, Joohan Woo   +13 more
doaj   +1 more source

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

, 2012
Nociceptors are a subset of small primary afferent neurons that respond to noxious chemical, thermal and mechanical stimuli. Ion channels in nociceptors respond differently to noxious stimuli and generate electrical signals in different ways. Anoctamin 1
Byeongjoon Lee, Harfe, Brian D., Back, Seung Keun, Young Duk Yang, Heung Sik Na, Kim, Tahnbee, Raouf, Ramin; id_orcid, Jesun Lee, Seung Keun Back, Tahnbee Kim, Yang, Young Duk, Jang, Yongwoo, Hawon Cho, Ramin Raouf, Brian D Harfe, Oh, Uhtaek, Fan Wang, Uhtaek Oh, Lee, Jesun, Cho, Hawon, Lee, Byeongjoon, Wood, John N., Na, Heung Sik, Yongwoo Jang, John N Wood, Wang, Fan   +25 more
core   +1 more source