Results 91 to 100 of about 123,298,984 (178)
The Journal of Physiology, EarlyView.Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura +4 more
wiley +1 more source
TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation
Biomedicine & Pharmacotherapy, 2020 Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment of coronary spasmodic disorders.TMEM16A-encoded anoctamin 1 (ANO1), a Ca2+ activated Cl- channel ...
Guijin, Ma +7 more
openaire +2 more sources
Rhabdomyolysis as an uncommon manifestation of anoctamin-5 muscular dystrophy [PDF]
Background: Anoctamin-5 (ANO5) muscular dystrophy is a rare neuromuscular disease. Muscular weakness and impaired gait may be evident at the moment of diagnosis, serving as defining characteristics of additional muscular dystrophies.
Marta Rodrigues +3 more
core +1 more source
Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013 Cystic fibrosis (CF) airway epithelium is constantly subjected to injury events due to chronic infection and inflammation. Moreover, abnormalities in CF airway epithelium repair have been described and contribute to the lung function decline seen in CF patients. In the last past years, it has been proposed that anoctamin 1 (ANO1), a Ca(2+)-activated Cl(
Ruffin, Manon +12 more
openaire +4 more sources
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function [PDF]
Kidney International, 2014 The role of calcium-activated chloride channels for renal function is unknown. By immunohistochemistry we demonstrate dominant expression of the recently identified calcium-activated chloride channels, Anoctamin 1 (Ano1, TMEM16A) in human and mouse proximal tubular epithelial (PTE) cells, with some expression in podocytes and other tubular segments ...
Diana, Faria +11 more
openaire +2 more sources
Expression of Anoctamin 1 in adult zebrafish [PDF]
, 2015 Anoctamin 1 (Ano1) codes for a calcium activated chloride channel that has recently been identified as a marker for gastrointestinal stromal tumors, as well as been shown to be selectively expressed by interstitial cells of Cajal (ICC) in the muscle ...
Brady, Clayton
core +2 more sources
Evolution and functional divergence of the anoctamin family of membrane proteins [PDF]
, 2010 Background: The anoctamin family of transmembrane proteins are found in all eukaryotes and consists of 10 members in vertebrates. Ano1 and ano2 were observed to have Ca(2+) activated Cl-channel activity.
Milenkovic, Vladimir M. +9 more
core +1 more source
Triggered Calcium Lightning Programs Cochlear Development
Exploration, Volume 6, Issue 5, October 2026.Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma +13 more
wiley +1 more source
Annals of Neurology, Volume 100, Issue 3, Page 547-558, September 2026.Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens +9 more
wiley +1 more source
Anoctamin‐1 channel localization in excitable domains of the heart (893.23)
The FASEB Journal, 2014 Calcium‐activated chloride (Cl Ca ) currents are widely distributed in cardiac tissues and have been implicated to play a role in cardiac physiology and pathophysiology. Anoctamin‐1 (Ano1) is a membrane protein that functions as a Cl Ca channel and has ...
Fiona Britton +2 more
openaire +1 more source