Results 61 to 70 of about 29,991,250 (177)

Anoctamin 6 regulates C2C12 myoblast proliferation. [PDF]

, 2014
Anoctamin 6 (Ano6) belongs to a conserved gene family (TMEM16) predicted to code for eight transmembrane proteins with putative Ca2+-activated chloride channel (CaCC) activity.
Andrew Mariano, Lixia Zhao, Lixia Zhao (174165), Sadia Mohsin, Audrey Torcaso (541543), Audrey Torcaso, Piming Zhao (439983), Andrew Mariano (541544), Renzhi Han (276195), Renzhi Han, Sadia Mohsin (541545), Piming Zhao, Li Xu, Li Xu (108702)   +13 more
core   +1 more source

Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2022
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
doaj   +1 more source

Effects of protein diet on expression of Anoctamin1 of Cajal cell in the nervous plexus of the stomach in male mice

Journal of the Pakistan Medical Association
Objective: To determine the association between a protein-rich diet and the expression of anoctamin 1 in Interstitial cells of Cajal within the muscle layer of the stomach wall in male mice.
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hiba Majed Rasol   +2 more
doaj   +1 more source

Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Acta Pharmaceutica Sinica B, 2021
Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu   +11 more
doaj   +1 more source

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells

, 2014
Polycystic kidney diseases are characterized by multiple bilateral renal cysts that gradually enlarge and lead to a decline in renal function. Cyst enlargement is driven by transepithelial chloride secretion, stimulated by enhanced levels of cyclic ...
Faria, Diana, Kunzelmann, Karl, Schreiber, Rainer, Eckardt, Kai-Uwe, Buchholz, Bjoern, Schley, Gunnar   +5 more
core   +1 more source

Novel mutations in the anoctamin 5 gene ( ANO5 ) associated with limb‐girdle muscular dystrophy 2L [PDF]

, 2013
Introduction: We present a Jordanian man with the typical LGMD 2L phenotype of early, asymmetric quadriceps weakness and subsequent biceps brachii weakness. Methods: Case report.
Little, Ann A., Mckeever, Paul E., Gruis, Kirsten L.   +2 more
core   +1 more source

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Nature Communications, 2019
The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells.
Anamika Dayal, Shu Fun J. Ng, Manfred Grabner   +2 more
doaj   +1 more source

Structure-Function Analysis of the Anion-Selective Pore of Anoctamin-1 [PDF]

Biophysical Journal, 2011
The anoctamins are a newly described family of anion channels. It has been proposed that anoctamin-1 (Ano1) has 8 transmembrane segments (TMDs) with a re-entrant loop between the 5th and 6th TMD that participates in forming the selectivity filter. To clarify the detailed structure and function of this region, we used cysteine accessibility scanning ...
Yu, Kuai, Cui, Yuanyuan, Hartzell, H. Criss   +2 more
openaire   +1 more source

The Nature of Cell‐Penetrating Poly(disulfide)s

Angewandte Chemie International Edition, EarlyView.
The mode of action of cell‐penetrating poly(disulfide)s (CPDs) is elucidated to understand thiol‐mediated uptake (TMU) in general and guide future efforts to control cellular entry for chemicals delivery and pathogen defense. ABSTRACT Cell‐penetrating poly(disulfide)s (CPDs) are the most popular thiol‐mediated uptake (TMU) tools for delivering attached
Saidbakhrom Saidjalolov, Giacomo Renno, Yuheng Zhang, Michael Cognet, Justin Neuman, Andreas Hennig, Naomi Sakai, Stefan Matile   +7 more
wiley   +1 more source

Channelopathies – subcellular localisation of mutant proteins taking anoctamin-4 und bestrophin-1 as examples [PDF]

Einleitung: Ziel der immunzytochemischen Versuche war es, Anoctamin-4 (ein calciumabhängiger Kationenkanal) und Bestrophin-1 (ein calciumabhängiger Chloridkanal) sowie verschiedene Mutanten dieser Ionenkanäle hinsichtlich ihrer zellulären Lokalisation zu
Sturm, Ronja Fini
core   +1 more source