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Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)
2022Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1), also known as TMEM16A. ANO1 allows the passive chloride flux that controls different physiological functions ranging from muscle contraction, fluid and hormone secretion, gastrointestinal motility, and electrical excitability.
Jorge, Arreola +5 more
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Calcium-regulated chloride channel anoctamin-1 is present in the suprachiasmatic nuclei of rats
NeuroReport, 2018Calcium-regulated chloride channel (CaCC) anoctamin-1 has been recently identified in neurons. In neurons, which express the Na-K-2Cl cotransporter, activation of CaCCs increases firing frequency, by reversion between the Cl equilibrium potential and the membrane resting potential, leading to membrane depolarization by Cl extrusion from the cell ...
Raúl, Aguilar-Roblero +7 more
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A mathematical model of the effects of anoctamin-1 loss on intestinal slow wave entrainment
2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017The interstitial cells of Cajal (ICC) generate electrophysiological events called slow waves that regulate the motility of the gastrointestinal (GI) tract. Recent studies have demonstrated that the Ca2+-activated Cl- -channel, encoded by the anoctamin1 (Ano1) protein, has a major role in regulating intestinal slow waves and motility.
Anna Qian +4 more
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Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease
Pediatric Surgery International, 2015Interstitial cells of Cajal (ICCs) are pacemaker cells involved in facilitating neurotransmission and the generation of slow electrical waves necessary for colonic peristalsis. Their distribution has been found to be abnormal in the aganglionic and ganglionic colon in Hirschsprung's disease (HSCR) using c-kit-labelling.
David, Coyle +4 more
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Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose
Cell and Tissue Research, 2012Calcium-activated chloride channels are expressed in chemosensory neurons of the nose and contribute to secretory processes and sensory signal transduction. These channels are thought to be members of the family of anoctamins (alternative name: TMEM16 proteins), which are opened by micromolar concentrations of intracellular Ca(2+).
Kristin, Dauner +4 more
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Dilated cardiomyopathy in patients with mutations in anoctamin 5
International Journal of Cardiology, 2013Karim Wahbi +2 more
exaly
Role of the Ca2+-activated Cl- channels bestrophin and anoctamin in epithelial cells
Biological Chemistry, 2011Karl Kunzelmann +2 more
exaly