Results 91 to 100 of about 107,476,558 (181)
Expression of Anoctamin 1 in adult zebrafish [PDF]
Anoctamin 1 (Ano1) codes for a calcium activated chloride channel that has recently been identified as a marker for gastrointestinal stromal tumors, as well as been shown to be selectively expressed by interstitial cells of Cajal (ICC) in the muscle ...
Brady, Clayton
core +2 more sources
Multiple Sclerosis and Viruses: « Liaisons Dangereuses »
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina +11 more
wiley +1 more source
Evolution and functional divergence of the anoctamin family of membrane proteins [PDF]
Background: The anoctamin family of transmembrane proteins are found in all eukaryotes and consists of 10 members in vertebrates. Ano1 and ano2 were observed to have Ca(2+) activated Cl-channel activity.
Milenkovic, Vladimir M. +9 more
core +1 more source
We explored genomic signatures of balancing selection and selective sweep in the northern medaka, Oryzias sakaizumii in Japan by performing whole‐genome resequencing of wild individuals. In addition, we reevaluated the population genetic structure and admixture of Oryzias latipes and O.
Shingo Fujimoto +9 more
wiley +1 more source
Generation of Muscle Tone in the Murine Internal Anal Sphincter by Anoctamin 1 [PDF]
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Kirchoff, Ileah
core
Background/Aims: Calcium-activated chloride channels (CaCCs) regulate numerous physiological processes including cell proliferation, migration, and extracellular matrix secretion. T16Ainh-A01 and CaCCinh-A01 are selective inhibitors of CaCCs.
Xiang-qin Tian +5 more
doaj +1 more source
Local Adaptation With Gene Flow Has a Polygenic Basis in a Threatened Coastal Songbird
Using a new chromosome‐level reference genome and whole‐genome sequencing, we show that the threatened, coastally specialized Atlantic song sparrow (Melospiza melodia atlantica) maintains adaptive divergence from a widespread generalist subspecies with divergently selected loci scattered across the genome rather than concentrated in low‐recombination ...
Jonathan D. Clark +3 more
wiley +1 more source
Average protein sizes, numbers of predicted TMSs (based on average hydropathy plots) and source phyla for each of the seven major families in the Anoctamin Superfamily.
Kevin J. Hendargo (5007257) +5 more
core +1 more source
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens +9 more
wiley +1 more source
TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation
Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment of coronary spasmodic disorders.TMEM16A-encoded anoctamin 1 (ANO1), a Ca2+ activated Cl- channel ...
Guijin, Ma +7 more
openaire +2 more sources

