Results 131 to 140 of about 2,952 (151)

Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

Current Topics in Medicinal Chemistry, 2021
ANO1, anoctamin 1(also known as TMEM16A), is the molecular basis of calcium-activated chloride channels with ten transmembrane segments which are widely expressed in mammalian cells, including epithelial cells, vascular smooth muscle tissues, electro-excitatory cells, and some tumor cells.
Xin Cao
exaly   +3 more sources

Anoctamin 1 in secretory epithelia

Cell Calcium, 2014
Fluid and electrolyte releasing from secretory epithelia are elaborately regulated by orchestrated activity of ion channels. The activity of chloride channel at the apical membrane decides on the direction and the rate of secretory fluid and electrolyte.
Yongwoo, Jang, Uhtaek, Oh
openaire   +2 more sources

Relationship between TMEM16A/anoctamin 1 and LRRC8A

Pflügers Archiv - European Journal of Physiology, 2016
TMEM16A/anoctamin 1/ANO1 and VRAC/LRRC8 are independent chloride channels activated either by increase in intracellular Ca(2+) or cell swelling, respectively. In previous studies, we observed overlapping properties for both types of channels. (i) TMEM16A/ANO1 and LRRC8 are inhibited by identical compounds, (ii) the volume-regulated anion channel VRAC ...
Roberta, Benedetto, Lalida, Sirianant, Ines, Pankonien, Podchanart, Wanitchakool, Jiraporn, Ousingsawat, Ines, Cabrita, Rainer, Schreiber, Margarida, Amaral, Karl, Kunzelmann   +8 more
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Anoctamin 1 expression in the mouse auditory brainstem

Cell and Tissue Research, 2014
Calcium-activated chloride channels (CaCCs) are involved in numerous physiological functions, including the epithelial movement of fluid. Anoctamin 1 (ANO1) has recently been cloned and characterized as a CaCC and is known to be expressed in various secretory epithelia and in nervous tissues such as the dorsal root ganglia and retina.
Sang Jae, Cho, Ji Hyun, Jeon, Do Ill, Chun, Sang Won, Yeo, In-Beom, Kim   +4 more
openaire   +2 more sources

Protons inhibit anoctamin 1 by competing with calcium

Cell Calcium, 2015
Cl(-) efflux through Ca(2+)-activated Cl(-) channels (CaCCs) in secretory epithelial cells plays a key role in the regulation of fluid secretion. The fluid and electrolyte secretion is closely related to intracellular pH. CaCCs have been known to be inhibited by intracellular acid.
Hyeyeon, Chun, Hawon, Cho, Jimi, Choi, Jesun, Lee, Sung Min, Kim, Hyungsup, Kim, Uhtaek, Oh   +6 more
openaire   +2 more sources

Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte

American Journal of Physiology-Cell Physiology, 2014
Iodide is captured by thyrocytes through the Na+/I− symporter (NIS) before being released into the follicular lumen, where it is oxidized and incorporated into thyroglobulin for the production of thyroid hormones. Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen.
Twyffels, L., Strickaert, A., Virreira, M., Massart, C., Van Sande, J., Wauquier, C., Beauwens, R., Dumont, J. E., Galietta, L. J., Boom, A., Kruys, V.   +10 more
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Altered anoctamin-1 and tyrosine phosphorylation in congenital ureteropelvic junction obstruction

Journal of Pediatric Surgery, 2020
Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis in children. The pathophysiology of UPJ obstruction and the exact mechanism of pelviureteral peristalsis are poorly understood. Anoctamin-1 (ANO1), a Ca2+-activated chloride channel, has been shown to play a key role in muscle wall contractions in the ...
Manuela, Hunziker, Anne-Marie, O'Donnell, Jan, Gosemann, Luis A, Alvarez, Prem, Puri   +4 more
openaire   +2 more sources

Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)

2022
Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1), also known as TMEM16A. ANO1 allows the passive chloride flux that controls different physiological functions ranging from muscle contraction, fluid and hormone secretion, gastrointestinal motility, and electrical excitability.
Jorge, Arreola, Patricia, Pérez-Cornejo, Guadalupe, Segura-Covarrubias, Nancy, Corral-Fernández, Daniel, León-Aparicio, María Luisa, Guzmán-Hernández   +5 more
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Calcium-regulated chloride channel anoctamin-1 is present in the suprachiasmatic nuclei of rats

NeuroReport, 2018
Calcium-regulated chloride channel (CaCC) anoctamin-1 has been recently identified in neurons. In neurons, which express the Na-K-2Cl cotransporter, activation of CaCCs increases firing frequency, by reversion between the Cl equilibrium potential and the membrane resting potential, leading to membrane depolarization by Cl extrusion from the cell ...
Raúl, Aguilar-Roblero, Adriana, Mejía-López, Dominique, Cortés-Pedroza, José L, Chavez-Juárez, Miguel A, Gutierrez-Monreal, Gabriela, Domínguez, Paula, Vergara, José, Segovia   +7 more
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A mathematical model of the effects of anoctamin-1 loss on intestinal slow wave entrainment

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017
The interstitial cells of Cajal (ICC) generate electrophysiological events called slow waves that regulate the motility of the gastrointestinal (GI) tract. Recent studies have demonstrated that the Ca2+-activated Cl- -channel, encoded by the anoctamin1 (Ano1) protein, has a major role in regulating intestinal slow waves and motility.
Anna Qian, Shawn Means, Leo K. Cheng, James Sneyd, Peng Du 0012   +4 more
openaire   +2 more sources