Results 91 to 100 of about 3,679,149 (318)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rasio pelarut etanol dan etil asetat pada proses ekstraksi terhadap karakteristik katekin dari gambir

JLI: Jurnal Litbang Industri, 2020
Gambir salah satu tanaman herbal yang mempunyai banyak manfaat, terutama untuk produk farmasi, kosmetik, pewarna dan lain sebagainya. Kandungan senyawa katekin yang tinggi pada gambir sangat dipengaruhi oleh proses ekstraksi yang dilakukan.
Inda Three Anova, Gustri Yeni
doaj   +1 more source

Optimization of the Polishing Efficiency and Torque by Using Taguchi Method and ANOVA in Robotic Polishing

, 2020
Surface finishing and polishing are important quality assurance processes in many manufacturing industries. A polished surface (low surface roughness) is linked with many useful properties other than providing an appealing gloss to the product, such as ...
Imran Mohsin, K. He, Zhenguo Li, Feifei Zhang, R. Du   +4 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Public Men’s Clinic: Men’s experiences of healthcare professionals and environment

African Journal of Primary Health Care & Family Medicine
Background: Men often face social barriers linked to norms and systemic issues when engaging with public healthcare services. South Africa’s first Public Men’s Clinic (PMC) was established in 2020, and now, 20 more clinics operate across the country ...
Lawrence L. Mamabolo, Isaac Sibiya, Fezile Buthelezi   +2 more
doaj   +1 more source

CLASSIFICATION OF FEATURE SELECTION BASED ON ARTIFICIAL NEURAL NETWORK [PDF]

, 2009
Pattern recognition (PR) is the central in a variety of engineering applications. For this reason, it is indeed vital to develop efficient pattern recognition systems that facilitate decision making automatically and reliably.
Hussain, Aini
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Multi-institutional Registry for Prostate Cancer Radiosurgery: An Observational Clinical Trial

Frontiers in Oncology, 2015
Title: Multi-institutional Registry for Prostate Cancer Radiosurgery: An Observational Clinical TrialAuthors: Debra Freeman, MD*; Gregg Dickerson, MD; Mark Perman, MDObjective: To report on the design, methodology and early outcome results of a multi ...
Debra eFreeman, Gregg eDickerson, Mark ePerman   +2 more
doaj   +1 more source

An ANOVA method of evaluating the specification uncertainty in roughness measurement [PDF]

, 2015
The specifications of roughness used in industry are normally incomplete, and the incompleteness can induce a significant uncertainty, called specification uncertainty.
Ding, Hao, Jiang, Xiang, Qi, Qunfen, Scott, Paul J.   +3 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source