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Insect Science, 2023
AbstractSuccessful completion of spermatogenesis is crucial for the perpetuation of the species. In Drosophila, spermatid individualization, a process involving changes in mitochondrial structure and function is critical to produce functional mature sperm. Ant2, encoding a mitochondrial adenine nucleotide translocase, is highly expressed in male testes
Zhen He +8 more
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AbstractSuccessful completion of spermatogenesis is crucial for the perpetuation of the species. In Drosophila, spermatid individualization, a process involving changes in mitochondrial structure and function is critical to produce functional mature sperm. Ant2, encoding a mitochondrial adenine nucleotide translocase, is highly expressed in male testes
Zhen He +8 more
openaire +2 more sources
ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs
Cell ResearchBidirectional transcription of mammalian mitochondrial DNA generates overlapping transcripts that are capable of forming double-stranded RNA (dsRNA) structures. Release of mitochondrial dsRNA into the cytosol activates the dsRNA-sensing immune signaling, which is a defense mechanism against microbial and viral attack and possibly cancer, but could ...
Pengcheng Wang +20 more
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[What is the specific role of ANT2 in cancer cells?].
Medecine sciences : M/S, 2005In the mitochondrial internal membrane, the adenine nucleotide translocator (ANT) carries out the ATP/ADP exchange between cytoplasm and mitochondrial matrix. Three isoforms with different kinetic properties are encoded from three different genes in Human: the muscle specific ANT1 and the ubiquitary ANT3 isoforms export ATP produced by mitochondrial ...
Arnaud, Chevrollier +2 more
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A74-21 Loss of Ant2 Promotes Senescence and Impairs Mitophagy in Pulmonary Fibrosis
American Journal of Respiratory and Critical Care MedicineAbstract Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive scarring of the alveolar tissue, resulting in shortness of breath, hypoxemia, and mortality. Ineffective lung repair and mitochondrial dysfunction have been implicated in IPF pathogenesis.
G Ting, C Kliment
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ANT2 promotes FDG uptake through HK2-VDAC1 interaction and predicts poor survival in various cancers
FDG PET is widely used to assess tumor glucose uptake and serves as a non-invasive prognostic tool for predicting overall survival (OS) in cancer patients. However, FDG uptake may vary between lesions within individuals and even between patients with the same cancer.Chul-Hee Lee +9 more
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