Results 131 to 140 of about 654,379 (320)
A stepwise emergence of evolution in the RNA world
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Identification of the first antagonist peptide that inhibits biological effects of interleukin-15
Interleukin-15 (IL-15) is a pro-inflammatory cytokine that is expressed in several autoimmune and inflammatory diseases. We have identified the 36-45 sequence KVTAMKCFLL on human IL-15 that is recognized by a soluble form of recombinant hIL-15Ra-Fc ...
Alicia Santos+20 more
doaj
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp+5 more
wiley +1 more source
COPPER AND ZINC AS ANTAGONISTIC AGENTS TO THE “ALKALI” SALTS IN SOILS
C. B. Lipman, W. F. Gericke
openalex +3 more sources
IMMUNOLOGIC STUDIES IN INSULIN RESISTANCE. III. MEASUREMENT OF AN INSULIN ANTAGONIST IN THE SERUM OF AN INSULIN-RESISTANT PATIENT BY THE BLOOD SUGAR CURVE METHOD IN MICE [PDF]
Francis C. Lowell
openalex +1 more source
Universal Boolean Logic in Cascading Networks [PDF]
Computational properties of networks that can undergo cascades are examined. It is shown that universal Boolean logic circuits can be computed by a global cascade having antagonistic interactions. Determinism and cascade frequency of this antagonistic model are explored,as well as its ability to perform classification. Universality of cascade logic may
arxiv
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens+8 more
wiley +1 more source
A QUANTITATIVE STUDY OF ANTAGONISTS OF ADRENALINE ON THE VESSELS OF THE RABBIT'S EAR [PDF]
A. Fleckenstein
openalex +1 more source
Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren+16 more
wiley +1 more source