Results 181 to 190 of about 1,028,152 (221)
Some of the next articles are maybe not open access.
1982
Publisher Summary This chapter presents the studies of the effects of metal antagonists, such as iron chelators, deferasirox, deferiprone, and deferoxamine. The effectiveness of iron chelators is illustrated by the tremendous improvements in both life expectancy and quality of life in patients with thalassemia because of structured and rigorous ...
openaire +2 more sources
Publisher Summary This chapter presents the studies of the effects of metal antagonists, such as iron chelators, deferasirox, deferiprone, and deferoxamine. The effectiveness of iron chelators is illustrated by the tremendous improvements in both life expectancy and quality of life in patients with thalassemia because of structured and rigorous ...
openaire +2 more sources
1966
Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
openaire +4 more sources
Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
openaire +4 more sources
Cellular and Molecular Life Sciences (CMLS), 1999
Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response.
Curley, G P, Blum, H, Humphries, M J
openaire +3 more sources
Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response.
Curley, G P, Blum, H, Humphries, M J
openaire +3 more sources
The Lancet, 1999
The very potent endogenous vasoconstrictor endothelin was discovered in 1988. We know now that there are three isoforms (1, 2, and 3) and two receptor subtypes (A and B). A whole range of peptide and non-peptide antagonists has been developed, some selective for A or B receptors and others with non-selective A/B antagonistic activity.
A, Benigni, G, Remuzzi
openaire +2 more sources
The very potent endogenous vasoconstrictor endothelin was discovered in 1988. We know now that there are three isoforms (1, 2, and 3) and two receptor subtypes (A and B). A whole range of peptide and non-peptide antagonists has been developed, some selective for A or B receptors and others with non-selective A/B antagonistic activity.
A, Benigni, G, Remuzzi
openaire +2 more sources
Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.
Science, 1991The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is an important mediator of several forms of neural and behavioral plasticity. The present studies examined whether NMDA receptors might be involved in the development of opiate tolerance ...
K. A. Trujillo, H. Akil
semanticscholar +1 more source
Progress in Cardiovascular Diseases, 2004
Calcium antagonists were introduced for the treatment of hypertension in the 1980s. Their use was subsequently expanded to additional disorders, such as angina pectoris, paroxysmal supraventricular tachycardias, hypertrophic cardiomyopathy, Raynaud phenomenon, pulmonary hypertension, diffuse esophageal spasms, and migraine.
Ehud, Grossman, Franz H, Messerli
openaire +2 more sources
Calcium antagonists were introduced for the treatment of hypertension in the 1980s. Their use was subsequently expanded to additional disorders, such as angina pectoris, paroxysmal supraventricular tachycardias, hypertrophic cardiomyopathy, Raynaud phenomenon, pulmonary hypertension, diffuse esophageal spasms, and migraine.
Ehud, Grossman, Franz H, Messerli
openaire +2 more sources
New England Journal of Medicine, 1948
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia treated by the intramuscular injection of a synthetic compound, 4-aminopteroylglutamic acid (aminopterin).
S. Farber +4 more
semanticscholar +1 more source
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia treated by the intramuscular injection of a synthetic compound, 4-aminopteroylglutamic acid (aminopterin).
S. Farber +4 more
semanticscholar +1 more source
Cardiology, 1985
At present nitrates remain the initial treatment for relief or prevention of angina in patients with coronary artery disease. In cases where nitrates and beta blockers have been used and are ineffective for managing effort angina, calcium antagonists may be substituted or added to the beta-blocking treatment. When the predominant symptom is rest angina,
C R, Conti +3 more
openaire +2 more sources
At present nitrates remain the initial treatment for relief or prevention of angina in patients with coronary artery disease. In cases where nitrates and beta blockers have been used and are ineffective for managing effort angina, calcium antagonists may be substituted or added to the beta-blocking treatment. When the predominant symptom is rest angina,
C R, Conti +3 more
openaire +2 more sources
Interleukin-1 receptor antagonist: role in biology.
Annual Review of Immunology, 1998The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response.
W. Arend +3 more
semanticscholar +1 more source
1998
Publisher Summary Inflammatory mediators contribute to the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD) suggesting that antagonists of mediator receptors or inhibitors of their synthesis would be beneficial in treatment.
K. Fan Chung, Peter J. Barnes
openaire +4 more sources
Publisher Summary Inflammatory mediators contribute to the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD) suggesting that antagonists of mediator receptors or inhibitors of their synthesis would be beneficial in treatment.
K. Fan Chung, Peter J. Barnes
openaire +4 more sources