Results 11 to 20 of about 1,519,714 (391)

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine [PDF]

New England Journal of Medicine, 2004
Background: Calcitonin gene–related peptide (CGRP) may have a causative role in migraine. We therefore hypothesized that a CGRP-receptor antagonist might be effective in the treatment of migraine attacks.
Diener, H.-C., Goadsby, P.J., Hall, D., Husstedt, I.G., Lesko, L.M., Meier, U., Olesen, J., Pollentier, S.   +7 more
core   +2 more sources

Characterization and selection of endophytic actinobacteria for growth and disease management of Tea (Camellia sinensis L.)

Frontiers in Plant Science, 2022
Endophytic microbes are vital for nutrient solubilization and uptake, growth, and survival of plants. Here, 88 endophytic actinobacteria (EnA) associated with five tea clones were isolated, assessed for their diversity, plant growth promoting (PGP), and ...
Shabiha Nudrat Hazarika, Shabiha Nudrat Hazarika, Kangkon Saikia, Debajit Thakur   +3 more
doaj   +1 more source

Curvularin Isolated From Phoma macrostoma Is an Antagonist of RhlR Quorum Sensing in Pseudomonas aeruginosa

Frontiers in Microbiology, 2022
Quorum sensing (QS) is an attractive target for the treatment of multidrug-resistant Pseudomonas aeruginosa, against which new antibiotics are urgently needed.
Ha-Young Choi, Ha-Young Choi, Duc Dat Le, Won-Gon Kim, Won-Gon Kim   +4 more
doaj   +1 more source

ACTH Antagonists [PDF]

Frontiers in Endocrinology, 2016
Adrenocorticotropin (ACTH) acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R), is unusual in that it is absolutely dependent on a small accessory protein, melanocortin receptor accessory protein (MRAP) for
Clark, AJ, Forfar, R, Hussain, M, Jerman, J, Mclver, E, Taylor, D, Chan, L   +6 more
openaire   +4 more sources

Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors

Frontiers in Pharmacology, 2023
Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth, Pallavi Nistala, Vy T. Nguyen, Jose M. Eltit, Richard A. Glennon, Małgorzata Dukat   +5 more
doaj   +1 more source

Identification of a novel P2X7 antagonist using structure-based virtual screening

Frontiers in Pharmacology, 2023
P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and inflammatory pain, and as such they are important drug targets in diseases of inflammatory origin. While several compounds targeting P2X4 and P2X7 receptors
Gaia Pasqualetto, Marika Zuanon, Andrea Brancale, Andrea Brancale, Mark T. Young   +4 more
doaj   +1 more source

Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity

Frontiers in Immunology, 2022
Infiltration of regulatory T cells (Tregs) in the tumor microenvironment suppresses anti-tumor immune response, and promotes tumor progression. Tumor necrosis factor receptor‐2 (TNFR2), which is highly expressed on Tregs, activates Tregs through nuclear ...
Yonglin Chen, Manxue Jia, Sharon Wang, Sherry Xu, Nanhai He   +4 more
doaj   +1 more source

A simple open source bioinformatic methodology for initial exploration of GPCR ligands’ agonistic/antagonistic properties

Pharmacology Research & Perspectives, 2020
Drug development is an arduous procedure, necessitating testing the interaction of a large number of potential candidates with potential interacting (macro)molecules.
Athanasios A. Panagiotopoulos, Christina Papachristofi, Konstantina Kalyvianaki, Panagiotis Malamos, Panayiotis A. Theodoropoulos, George Notas, Theodora Calogeropoulou, Elias Castanas, Marilena Kampa   +8 more
doaj   +1 more source

KA-1002, a Novel Lysophosphatidic Acid Signaling Antagonist, Alleviates Bovine Tracheal Cell Disruption and Inflammation

Animals, 2020
The industrial livestock environment can cause stress and weakened immunity in cattle, leading to microbial infections which reduce productivity. As such, there is a need for an effective therapeutic agent that can alleviate uncontrolled destructive ...
Hee-su Shin, Miok Kim, Kwang Soo Kim, Yong Ki Min, Chang Hoon Lee   +4 more
doaj   +1 more source

Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology

Frontiers in Pharmacology, 2022
Extracellular ATP is a critical signaling molecule that is found in a wide range of concentrations across cellular environments. The family of nonselective cation channels that sense extracellular ATP, termed P2X receptors (P2XRs), is composed of seven ...
Adam C. Oken, Ipsita Krishnamurthy, Jonathan C. Savage, Nicolas E. Lisi, Michael H. Godsey, Steven E. Mansoor, Steven E. Mansoor   +6 more
doaj   +1 more source